Purpose: The purpose of this study was to identify the factors influencing college life adjustment in nursing students. Methods: The subjects consisted of 206 nursing students. Data were collected from December 6 to December 13, 2012. Data analysis was done using descriptive statistics, t-test, ANOVA, Pearson’s correlational coefficients and multiple regression with SPSS WIN v 20.0. Result: The mean scores of ego-identity (3.53±48), social problem-solving ability (3.41±.42), and college life adjustment (5.27±.91) were above average. College life adjustment was significantly different according to ego-identity, academic performance, and perceived health state. Ego-identity, academic performance, and perceived health state were influencing factors of college life adjustment (53.2%). Conclusion: It is necessary to develop an education program to improve ego-identity, academic performance, and perceived health state to help nursing students to adjust to their college life more effectively.