지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 394 - 399 (6page)
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초록· 키워드
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Astragalus membranaceus Bunge is used in herbal medicine in Eastern Asian countries including Korea. In this study, we assessed the effects of A. membranaceus extract (AM) on the aquaporin-3 (AQP3) protein expression in HaCaT cells. AM did not affect viability of HaCaT cells. AQP3 expression and cell migration seem to be maximal at 100 μg/mL concentration. Epidermal growth factor receptor (EGFR) kinase inhibitor, PD153035, blocked AM-induced AQP3 expression and cell migration. In addition, an 80% ethanol extracts of herbal prescription, SinhyoTakleesan (ST), which is composed of A. membranaceus, Angelicae gigantis, Glycyrrhiza glabra Linne, and Lonicera japonica Flos also induced AQP3 expression at 20 μg/mL in HaCaT cells. Collectively, these results suggest that AM induce AQP3 expression via EGFR pathway.
목차
Abstract
1. 서론
2. 재료 및 방법
3. 결과 및 고찰
4. 결론
REFERENCES
참고문헌 (33)
참고문헌 신청
1. [학술지(정기간행물)] - Agre, P. / 2002 / Aquaporin water channels- from atomic structure to clinical medicine / J. Physiol 542 : 3 ~ 16
2. [학술지(정기간행물)] - Rojek, A. / 2008 / A current view of the mammalian aquaglyceroporins / Ann. Rev. Physiol 70 : 301 ~ 327
3. [학술지(정기간행물)] - Verkman, A. S. / 2000 / Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice / Exp. Physiol 85 : 233 ~ 241
4. [학술지(정기간행물)] - Verkman, A. S. / 2006 / Roles of aquaporins in kidney revealed by transgenic mice / Semin. Nephrol 26 : 200 ~ 208
5. [학술지(정기간행물)] - Manley G. T. / 2000 / Aquaporin-4 deletion in mice recduces brain edema after acute water intoxication and ischemic stroke / Nat. Med 6 : 159 ~ 163
2. [학술지(정기간행물)] - Rojek, A. / 2008 / A current view of the mammalian aquaglyceroporins / Ann. Rev. Physiol 70 : 301 ~ 327
3. [학술지(정기간행물)] - Verkman, A. S. / 2000 / Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice / Exp. Physiol 85 : 233 ~ 241
4. [학술지(정기간행물)] - Verkman, A. S. / 2006 / Roles of aquaporins in kidney revealed by transgenic mice / Semin. Nephrol 26 : 200 ~ 208
5. [학술지(정기간행물)] - Manley G. T. / 2000 / Aquaporin-4 deletion in mice recduces brain edema after acute water intoxication and ischemic stroke / Nat. Med 6 : 159 ~ 163
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UCI(KEPA) : I410-ECN-0101-2015-400-001299833