지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 28 - 33 (6page)
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초록· 키워드
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Background: Panax notoginseng has been used as a general tonic agent to invigorate human body for millennia in China and continued to be used until present.
Methods: Some chromatographic methods were performed to isolate pure triterpenoids, and their structures were determined by nuclear magnetic resonance (NMR) experiments. Anti-diabetes activities of isolated compounds were evaluated through their inhibitory activity of protein tyrosine phosphatase 1B (PTP1B) enzyme.
Results and Conclusion: Three new dammarane-type triterpenoids, notoginsenoside-LX (1), notoginsenoside-LY (2), and notoginsenoside-FZ (3) together with eighteen known compounds were isolated from the Panax notoginseng leaves. The structure-activity relationship of the compounds with dammaranetype triterpenoids and their PTP1B inhibitory activity were also reported. Results showed that compounds 2, 15, 20, and 21 can significantly inhibit the enzyme activity of PTP1B in a dose-dependent manner, with inhibitory concentration 50 (IC<SUB>50</SUB>) values of 29.08 mM, 21.27 μM, 28.12 μM, and 26.59 μM, respectively. The results suggested that Panax notoginseng leaves might have potential as a new therapeutic agent for the treatment of diabetes.
Methods: Some chromatographic methods were performed to isolate pure triterpenoids, and their structures were determined by nuclear magnetic resonance (NMR) experiments. Anti-diabetes activities of isolated compounds were evaluated through their inhibitory activity of protein tyrosine phosphatase 1B (PTP1B) enzyme.
Results and Conclusion: Three new dammarane-type triterpenoids, notoginsenoside-LX (1), notoginsenoside-LY (2), and notoginsenoside-FZ (3) together with eighteen known compounds were isolated from the Panax notoginseng leaves. The structure-activity relationship of the compounds with dammaranetype triterpenoids and their PTP1B inhibitory activity were also reported. Results showed that compounds 2, 15, 20, and 21 can significantly inhibit the enzyme activity of PTP1B in a dose-dependent manner, with inhibitory concentration 50 (IC<SUB>50</SUB>) values of 29.08 mM, 21.27 μM, 28.12 μM, and 26.59 μM, respectively. The results suggested that Panax notoginseng leaves might have potential as a new therapeutic agent for the treatment of diabetes.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
References
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Yang Y / 2008 / Scientific substantiation of functional food health claims in China / J Nutr 138 : 1199 ~ 1205
2. [학술지(정기간행물)] - Sun S / 2010 / Effects of steaming the root of Panax notoginseng on chemical composition and anticancer activities / Food Chem 118 : 307 ~ 314
3. [학술지(정기간행물)] - Kwan CY / 2000 / Effects of Panax notoginseng saponins on vascular endothelial cells in vitro / Acta Pharmacol Sin 21 : 1101 ~ 1105
4. [학술지(정기간행물)] - Li SH / 1999 / Anti-inflammation effects of total saponins of Panax notoginseng / Acta Pharmacol Sin 20 : 551 ~ 554
5. [학술지(정기간행물)] - Lee JH / 2006 / Ginsenoside Rg1 helps mice resist to disseminated candidiasis by Th1 type differentiation of CD4þ T cell / Int Immunopharmacol 6 : 1424 ~ 1430
2. [학술지(정기간행물)] - Sun S / 2010 / Effects of steaming the root of Panax notoginseng on chemical composition and anticancer activities / Food Chem 118 : 307 ~ 314
3. [학술지(정기간행물)] - Kwan CY / 2000 / Effects of Panax notoginseng saponins on vascular endothelial cells in vitro / Acta Pharmacol Sin 21 : 1101 ~ 1105
4. [학술지(정기간행물)] - Li SH / 1999 / Anti-inflammation effects of total saponins of Panax notoginseng / Acta Pharmacol Sin 20 : 551 ~ 554
5. [학술지(정기간행물)] - Lee JH / 2006 / Ginsenoside Rg1 helps mice resist to disseminated candidiasis by Th1 type differentiation of CD4þ T cell / Int Immunopharmacol 6 : 1424 ~ 1430
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UCI(KEPA) : I410-ECN-0101-2015-520-001297350