지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Scutellaria baicalensis Georgi, which has been known to be able to clear away heat and remove dampness, was used for febrile disease. It is now clear that Advanced glycation end products (AGEs) play major roles in the pathogenesis of diabetic complications such as atherosclerosis. In this study, we examined whether Scutellaria baicalensis Georgi suppress the AGE mediated inflammatory responses in the THP-1 cells. AGE treatment increased the gene expression of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), monocyte chemotactic protein-1 (MCP-1) and cyclooxygenase-2 (COX-2). Reverse transcriptase-polymerase chain reaction and Western blot analysis revealed that S. baicalensis had inhibitory effects on the expression of pro-inflammatory genes and protein levels in AGE-treated THP-1 cells. S. baicalensis had also reduced the production of ROS in the AGE-treated THP-1 cells. These results suggest that S. baicalensis has inhibitory effects for the development of diabetic vascular complication.
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참고문헌 (52)
참고문헌 신청
1. [학술지(정기간행물)] - Hu, F. B. / 2001 / Diet, lifestyle, and the risk of type 2 diabetes mellitus in women / N Engl J Med 345 : 790 ~ 797
2. [학술지(정기간행물)] - Zimmet, P. / 2001 / Global and societal implications of the diabetes epidemic / Nature 414 : 782 ~ 787
3. [학술지(정기간행물)] - Kahn, S. E. / 2006 / Mechanisms linking obesity to insulin resistance and type 2 diabetes / Nature 444 : 840 ~ 846
4. [학술지(정기간행물)] - Kathryn, E. / 2005 / Hotamisligil. Inflammation, stress, and diabetes / J Clin Invest 115 (5) : 1111 ~ 1119
5. [학술지(정기간행물)] - Schmidt, M. I. / 2005 / Subclinical inflammation and obesity, diabetes and related disorders / Drug Discovery Today : Disease Mechanisms 3 (3) : 307 ~ 312
2. [학술지(정기간행물)] - Zimmet, P. / 2001 / Global and societal implications of the diabetes epidemic / Nature 414 : 782 ~ 787
3. [학술지(정기간행물)] - Kahn, S. E. / 2006 / Mechanisms linking obesity to insulin resistance and type 2 diabetes / Nature 444 : 840 ~ 846
4. [학술지(정기간행물)] - Kathryn, E. / 2005 / Hotamisligil. Inflammation, stress, and diabetes / J Clin Invest 115 (5) : 1111 ~ 1119
5. [학술지(정기간행물)] - Schmidt, M. I. / 2005 / Subclinical inflammation and obesity, diabetes and related disorders / Drug Discovery Today : Disease Mechanisms 3 (3) : 307 ~ 312
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