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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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An extract of Alnus japonica (Betulaceae) cortex has been traditionally used for purifying blood, and curing feces containing blood, enteritis, diarrhea, alcoholism and cut wounds. In the present study, we demonstrated that the ethanol extract of Alnus japonica (EAJ) exhibited significantly cytotoxicity in human colon adenocarcinoma HT-29 cells. The results showed that the induction of apoptosis in HT-29 cells by EAJ was characterized by chromatin condensation and activation of caspase-3. EAJ-induced activation of caspase-9 and -3 caused the cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. The expressions of Bcl-2 and Bid were reduced by EAJ in HT-29 cells, whereas pro-apoptotic protein Bak was increased in the cells. EAJ-induced, dose-dependent induction of apoptosis was accompanied by sustained phosphorylation of MAP kinases (JNK and p38 MAPK), ASK1, and p53. NAC administration, a scavenger of ROS, reversed EAJ-induced cell death. In conclusion, these results indicated that EAJ can cause apoptosis through a ROS-mitochondria-caspases-dependent pathway in human HT-29 cells.
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1. [학술지(정기간행물)] - Byung-Keun Yang / 2009 / Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model / Mycobiology 37 (2) : 128 ~ 132
2. [학술지(정기간행물)] - Denipote, F. G. / 2010 / Probiotics and prebiotics in primary care for colon cancer / Arq. Gastroenterol 47 (1) : 93 ~ 98
3. [학술지(정기간행물)] - 류덕선 / 2009 / Anti-Proliferative Effect of Polysaccharides from Salicornia herbacea on Induction of G2/M Arrest and Apoptosis in Human Colon Cancer Cells / Journal of Microbiology and Biotechnology 19 (11) : 1482 ~ 1489
4. [학술지(정기간행물)] - Liu, J. J. / 2002 / Boswellic Acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells / Carcinogenesis 23 (12) : 2087 ~ 2093
5. [학술지(정기간행물)] - Pathak, S. / 2009 / Apoptotic signaling induced by benzamide riboside : an in vitro study / Mol Cell Biochem 328 (2) : 67 ~ 73
2. [학술지(정기간행물)] - Denipote, F. G. / 2010 / Probiotics and prebiotics in primary care for colon cancer / Arq. Gastroenterol 47 (1) : 93 ~ 98
3. [학술지(정기간행물)] - 류덕선 / 2009 / Anti-Proliferative Effect of Polysaccharides from Salicornia herbacea on Induction of G2/M Arrest and Apoptosis in Human Colon Cancer Cells / Journal of Microbiology and Biotechnology 19 (11) : 1482 ~ 1489
4. [학술지(정기간행물)] - Liu, J. J. / 2002 / Boswellic Acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells / Carcinogenesis 23 (12) : 2087 ~ 2093
5. [학술지(정기간행물)] - Pathak, S. / 2009 / Apoptotic signaling induced by benzamide riboside : an in vitro study / Mol Cell Biochem 328 (2) : 67 ~ 73
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