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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The purpose of this study is to investigate the effects of Carthami Flos on interstitial cells of Cajal in the gastrointestinal tract. Many regions of the tunica muscularis of the gastrointestinal (GI) tract display spontaneous contraction. These spontaneous contractions are mediated by periodic generation of electrical slow waves. Recent studies have shown that the interstitial cells of Cajal (ICCs) act as pacemakers and conductors of electrical slow waves in gastrointestinal smooth muscles. We investigated the cytotoxicity activity, antioxidant activity, and pacemaking activity. The cytotoxicity activity was measured by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. Antioxidant activities were determined by DPPH (1.1-diphenyl-2-picrylhydrazyl) radical scavenging capacity assay and DCFH-DA (2,7-dichlorofluorescein diacetate) method. The effects of Carthami Flos on the pacemaker potentials in cultured ICCs from murine small intestine were investigated by using whole-cell patch-clamp techniques at 30℃. The addition of Carthami Flos (5, 10, 30 μg/ml) depolarized the resting membrane potentials in a concentration dependent manner. These results suggest that the GI tract can be targets for Carthami Flos, and their interaction can affect intestinal motility.
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참고문헌 (28)
참고문헌 신청
1. [단행본] - 최한기 / / 고농서국역총서11-농정회요Ⅱ (農政會要) / 농촌진흥청 : 271 ~ 277
2. [학술지(정기간행물)] - 최성희 / 2004 / 홍화꽃 및 홍화씨의 휘발성성분 / 한국식품과학회지 14 (2) : 36 ~ 42
3. [학술지(정기간행물)] - 김미진 / 2004 / Anti-wrinkle Effect of Safflower (Carthamus tinctorius) Seed Extract (I) / 대한화장품학회지 30 (1) : 15 ~ 22
4. [학술지(정기간행물)] - Zhang, H.L. / 1996 / Novel antioxidants from safflower (Carthamus tinctorius L.) / oil cake. Chem. Pharm. Bull 44 : 874 ~ 876
5. [학술지(정기간행물)] - Zhang, H.L. / 1997 / Antioxidative compounds isolated from safflower (Carthamus tinctorius L.) / oil cake. Chem. Pharm. Bull 45 (12) : 1910 ~ 1914
2. [학술지(정기간행물)] - 최성희 / 2004 / 홍화꽃 및 홍화씨의 휘발성성분 / 한국식품과학회지 14 (2) : 36 ~ 42
3. [학술지(정기간행물)] - 김미진 / 2004 / Anti-wrinkle Effect of Safflower (Carthamus tinctorius) Seed Extract (I) / 대한화장품학회지 30 (1) : 15 ~ 22
4. [학술지(정기간행물)] - Zhang, H.L. / 1996 / Novel antioxidants from safflower (Carthamus tinctorius L.) / oil cake. Chem. Pharm. Bull 44 : 874 ~ 876
5. [학술지(정기간행물)] - Zhang, H.L. / 1997 / Antioxidative compounds isolated from safflower (Carthamus tinctorius L.) / oil cake. Chem. Pharm. Bull 45 (12) : 1910 ~ 1914
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