지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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In order to validate the use of Saussurea Lappa as an anti-inflammatory drug in the traditional Korean medicine, I have investigated the effects of water-soluble extract of Saussurea Lappa (ESL) on the production of pro-inflammatory tumor necrosis factor-alpha (TNF-α) in murine RAW 264.7 macrophages stimulated with the endotoxin lipopolysaccharide (LPS). The extract inhibited dose-dependently TNF-α production without its cytotoxic effect on the macrophages, as measured by enzyme-linked immunosorbent assay, and significantly decreased mRNA levels of TNF-α, as determined using reverse transcription polymerase chain reaction. The extract also inhibited LPS-induced activation of nuclear factor- κB, thereby resulting in TNF-α gene expression. These results suggest that ESL may have therapeutic potential in the control of inflammatory diseases mediated by activated macrophages.
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참고문헌 (21)
참고문헌 신청
1. [단행본] - 신민교 / 1997 / 임상본초학 / 남산당 : 469 ~ 470
2. [학술지(정기간행물)] - Ko, S.G. / 2004 / Induction of apoptosis by Saussurea lappa and Pharbitis nil on AGS gastric cancer cells / Biol Pharm Bull 27 (10) : 1604 ~ 1610
3. [학술지(정기간행물)] - Oh, G.S. / 2004 / Dehydrocostus lactone enhances tumor necrosis factor-alpha-induced apoptosis of human leukemia HL-60 cells / IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 26 (2) : 163 ~ 175
4. [학술지(정기간행물)] - Cho, J.Y. / 2004 / Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines / Eur J Pharmacol 492 (2) : 85 ~ 94
5. [학술지(정기간행물)] - Damre, A.A. / 2003 / Evaluation of sesquiterpene lactone fraction of Saussurea lappa on transudative, exudative and proliferative phases of inflammation / Phytother Res 17 (7) : 722 ~ 725
2. [학술지(정기간행물)] - Ko, S.G. / 2004 / Induction of apoptosis by Saussurea lappa and Pharbitis nil on AGS gastric cancer cells / Biol Pharm Bull 27 (10) : 1604 ~ 1610
3. [학술지(정기간행물)] - Oh, G.S. / 2004 / Dehydrocostus lactone enhances tumor necrosis factor-alpha-induced apoptosis of human leukemia HL-60 cells / IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 26 (2) : 163 ~ 175
4. [학술지(정기간행물)] - Cho, J.Y. / 2004 / Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines / Eur J Pharmacol 492 (2) : 85 ~ 94
5. [학술지(정기간행물)] - Damre, A.A. / 2003 / Evaluation of sesquiterpene lactone fraction of Saussurea lappa on transudative, exudative and proliferative phases of inflammation / Phytother Res 17 (7) : 722 ~ 725
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