지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.8
- 수록면
- 437 - 445 (9page)
- DOI
- 10.15188/kjopp.2013.08.27.4.437
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This study was investigated to evaluate the vasorelaxant effect of Rubus coreanus(RC) extract on contracted rabbit carotid artery and its mechanism. To study the effect of RC extract on contracted rabbit carotid arterial strips, arterial strips with intact or damaged endothelium were used for experiment using organ bath. The pre-contracted arterial strips with norepinephrine(NE) or potassium chloride(KCl) was treated with various concentrations of an extract of RC(0.01, 0.03, 0.1, 0.3 and 1.0 ㎎/㎖). To determine the mechanisms of RC-induced vasorelaxant, RC extract was infused into contracted arterial rings which had been pretreated by indomethacin(IM), tetraethylammonium chloride(TEA), Nω-nitro-L-arginine (L-NNA), methylene blue(MB). And calcium chloride(Ca) 1 mM was infused into precontracted arterial ring induced by NE or KCl after treatment of RC extract in Ca<SUP>2+</SUP>-free krebs solution. Cytotoxic activity of RC extract on human umbilical vein endothelial cell(HUVEC) was measured by MTT assay, and nitric oxide(NO) prodution was measured by Griess reagent. RC extract revealed significant relaxation on NE-induced arterial contraction, but didn"t relax on KCl-induced arterial contraction. RC extract also had an effective relaxation to the intact endothelium arterial ring, but not the damaged endothelium arterial ring. Treatment of IM, TEA, L-NNA, MB reduced the relaxation of RC extract. Pretreatment of RC extract inhibited the contraction by influx of extracellular Ca<SUP>2+</SUP> in contracted arterial ring induced by NE, but it didn"t work the contraction by influx of extracellular Ca<SUP>2+</SUP> in contracted arterial ring induced by KCl in Ca<SUP>2+</SUP>-free krebs solution. RC extract increased nitric oxide production on HUVEC. This study indicated that the relaxation effect of RC extract on contracted rabbit carotid artery is related with NO-cGMP pathway, EDHF, prostacyclin.
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재료 및 방법
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참고문헌
참고문헌 (31)
참고문헌 신청
1. [학술지(정기간행물)] - 박창규 / 2006 / 고혈압환자에서 뇌졸중 발병위험요인과 치료행태에 관한 연구 / 대한고혈압학회지 12 : 16 ~ 24
2. [학술지(정기간행물)] - Park, J. B. / 2000 / Effects of antihypertensive therapy on hypertensive vascular disease / Current Hypertension Reports 2 : 280 ~ 288
3. [학술지(정기간행물)] - Hsueh, W. A. / 1997 / Endothelium in insulin resistance and diabetes / Diabetes Reviews 5 : 343 ~ 352
4. [학술지(정기간행물)] - Brusse, R. / 1993 / The epithelial organ / Current Opinion in Cardiology 8 : 719 ~ 727
5. [학술지(정기간행물)] - Vane J. R. / 1990 / Regulatory functions of the vascular endothelium / The New England Journal of Medicine 323 : 27 ~ 36
2. [학술지(정기간행물)] - Park, J. B. / 2000 / Effects of antihypertensive therapy on hypertensive vascular disease / Current Hypertension Reports 2 : 280 ~ 288
3. [학술지(정기간행물)] - Hsueh, W. A. / 1997 / Endothelium in insulin resistance and diabetes / Diabetes Reviews 5 : 343 ~ 352
4. [학술지(정기간행물)] - Brusse, R. / 1993 / The epithelial organ / Current Opinion in Cardiology 8 : 719 ~ 727
5. [학술지(정기간행물)] - Vane J. R. / 1990 / Regulatory functions of the vascular endothelium / The New England Journal of Medicine 323 : 27 ~ 36
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