지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 303 - 309 (7page)
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초록· 키워드
오류제보하기
Oncolytic vaccinia virus is an engineered vaccinia virus that selectively destroys cancer cells and induces tumor immune response. Oncolytic vaccinia expressing mouse GM-CSF showed cytotoxic activity against various kinds of cancer cells when oncolytic vaccinia virus expressing human GM-CSF and mouse GM-CSF is intravenously administered in the mouse CT26 colon tumor model. Cancer cells treated with isolated immunoglobulin G from the serum with complement showed these cytotoxic activity and complement observed dose-dependent cytotoxic effect. These results suggest that oncolytic vaccinia virus expressing mouse GM-CSF can increase oncolytic vaccinia virus by inducing anticancer antibody in a mouse tumor model. Further studies are needed on antitumor immunity of GM-CSF.
목차
서론
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Breitbach CJ / 2007 / Targeted inflammation during oncolytic virus therapy severely compromises tumor blood flow / Mol Ther 15 : 1686 ~ 1693
2. [학술지(정기간행물)] - Bubenik J / 1996 / Cytokine gene-modified vaccines in the therapy of cancer / Pharmacol Ther 69 : 1 ~ 14
3. [학술지(정기간행물)] - Burger JA / 2000 / Local and systemic effects after adenoviral transfer of the murine granulocyte-macrophage colony-stimulating factor gene into mice / Br J Haematol 108 : 641 ~ 652
4. [학술지(정기간행물)] - Chase M / 1998 / An oncolytic viral mutant that delivers the CYP2B1 transgene and augments cyclophosphamide chemotherapy / Nat Biotechnol 16 : 444 ~ 448
5. [학술지(정기간행물)] - Dranoff G / 2002 / GM-CSF-based cancer vaccines / Immunol Rev 188 : 147 ~ 154
2. [학술지(정기간행물)] - Bubenik J / 1996 / Cytokine gene-modified vaccines in the therapy of cancer / Pharmacol Ther 69 : 1 ~ 14
3. [학술지(정기간행물)] - Burger JA / 2000 / Local and systemic effects after adenoviral transfer of the murine granulocyte-macrophage colony-stimulating factor gene into mice / Br J Haematol 108 : 641 ~ 652
4. [학술지(정기간행물)] - Chase M / 1998 / An oncolytic viral mutant that delivers the CYP2B1 transgene and augments cyclophosphamide chemotherapy / Nat Biotechnol 16 : 444 ~ 448
5. [학술지(정기간행물)] - Dranoff G / 2002 / GM-CSF-based cancer vaccines / Immunol Rev 188 : 147 ~ 154
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