지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Asthma is an allergic inflammation and house dust mite (HDM) is a major allergen to induce asthma pathogenesis. Regulation of eosinophil apoptosis is an essential immune process and its dysregulation is implicated in asthma. In the present study, we examined the effects of HDM on spontaneous apoptosis of asthmatic eosinophils and on cytokine secretion in eosinophils of normal subjects including non-atopic and atopic normal. Extract of Dermatophagoides pteronissinus (DP) inhibited eosinophil apoptosis in a time-dependent manner. DP increased the secretion of G-CSF, GM-SCF, and IL-4, which is involved in suppression of eosinophil apoptosis, but IL-5 expression was not altered after DP stimulation. DP also elevated the release of IL-6, IL-8, tumor necrosis factor-α (TNF-α) and CCL2, which are anti-apoptotic or survival factors. The secretion of G-CSF, GM-CSF, IL-6, IL-8, and TNF-α due to DP is higher in atopic normal than that in non-atopic normal. In conclusion, DP increases the survival of eosinophils and its mechanism may be associated with cytokine release. These findings may enable elucidation of asthma pathogenesis induced by HDM.
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REFERENCES
참고문헌 (12)
참고문헌 신청
1. [학술지(정기간행물)] - Berry M / 2007 / Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma / Thorax 62 : 1043 ~ 1049
2. [학술지(정기간행물)] - Corrigan C / 2004 / Mechanisms of intrinsic asthma / Curr Opin Allergy Clin Immunol 4 : 53 ~ 56
3. [학술지(정기간행물)] - Filipović M / 2001 / The role of eosinophils in asthma / Medicine and Biology 8 : 6 ~ 10
4. [학술지(정기간행물)] - Gaffin JM / 2009 / The role of indoor allergens in the development of asthma / Curr Opin Allergy Clin Immunol 9 : 128 ~ 135
5. [학술지(정기간행물)] - Holgate ST / 2008 / Pathogenesis of asthma / Clin Exp Allergy 38 : 872 ~ 897
2. [학술지(정기간행물)] - Corrigan C / 2004 / Mechanisms of intrinsic asthma / Curr Opin Allergy Clin Immunol 4 : 53 ~ 56
3. [학술지(정기간행물)] - Filipović M / 2001 / The role of eosinophils in asthma / Medicine and Biology 8 : 6 ~ 10
4. [학술지(정기간행물)] - Gaffin JM / 2009 / The role of indoor allergens in the development of asthma / Curr Opin Allergy Clin Immunol 9 : 128 ~ 135
5. [학술지(정기간행물)] - Holgate ST / 2008 / Pathogenesis of asthma / Clin Exp Allergy 38 : 872 ~ 897
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UCI(KEPA) : I410-ECN-0101-2015-500-001321444