지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: Evidence-based medicine(EBM) advocates the use of up-to-date “best” scientific evidence from health care research as the basis for making medical decisions. EBM also has been applied to traditional Korean medicine(TKM), especially in the field of safety. Recently, the standard prescription for TKM by Korea Institute of Oriental Medicine was published based on toxic index from various toxicity tests. However, there are some limitations when the results from the study based on EBM are applied in clinics. To overcome these imitations, the term “evidence-based practical medicine” was developed and defined as clinically applicable results from the study based on EBM. And safety classification for TKM was suggested as an example of evidence-based practical medicine.
Methods: For safety classification for TKM, the data for LD<SUB>50</SUB>(50% lethal dose), which was transformed to theoretical LD<SUB>1</SUB>(1% lethal dose), was analyzed as one of tools for EMB study and divided by maximum dose used in clinics.
Results and Conclusions: As a result, human equivalent dose(HED)-based MOS(margin of safety) for korean traditional medicine was calculated and used for safety classification with 5 categories. These categories would be helpful for oriental medicine clinicians to decide the increase and decrease of dosage according to various factors such as patient’s sensitivity, potential toxicity of herbal medicines, clinician’s experience for better cure. Thus, this safety classification provides some evidences enough that evidence-based practical medicine should be not the same with EBM and defined differently from EBM.
Methods: For safety classification for TKM, the data for LD<SUB>50</SUB>(50% lethal dose), which was transformed to theoretical LD<SUB>1</SUB>(1% lethal dose), was analyzed as one of tools for EMB study and divided by maximum dose used in clinics.
Results and Conclusions: As a result, human equivalent dose(HED)-based MOS(margin of safety) for korean traditional medicine was calculated and used for safety classification with 5 categories. These categories would be helpful for oriental medicine clinicians to decide the increase and decrease of dosage according to various factors such as patient’s sensitivity, potential toxicity of herbal medicines, clinician’s experience for better cure. Thus, this safety classification provides some evidences enough that evidence-based practical medicine should be not the same with EBM and defined differently from EBM.
목차
서론
연구방법
결과 및 고찰
요약 및 결론
참고문헌
참고문헌 (18)
참고문헌 신청
1. [보고서] - Korea Institute for oriental medicine / 2011 / standard prescription for Korean medicine
2. [단행본] - Lee SD / 2012 / Toxicology for herbal medicine I / Korean Studies Information(Ltd.)
3. [보고서] - KFDA / 2012 / Research about management system of herbal medicine classification for safety
4. [학술지(정기간행물)] - Sackett DL / 1996 / Evidence-based medicine: what it is and what it isn't / BMJ 312 (7023) : 71 ~ 72
5. [학술지(정기간행물)] - An HS / 2013 / Application and development of Evidence-based Medicine / The korean Journal of pancreas and Biliary Tract 18 (1)
2. [단행본] - Lee SD / 2012 / Toxicology for herbal medicine I / Korean Studies Information(Ltd.)
3. [보고서] - KFDA / 2012 / Research about management system of herbal medicine classification for safety
4. [학술지(정기간행물)] - Sackett DL / 1996 / Evidence-based medicine: what it is and what it isn't / BMJ 312 (7023) : 71 ~ 72
5. [학술지(정기간행물)] - An HS / 2013 / Application and development of Evidence-based Medicine / The korean Journal of pancreas and Biliary Tract 18 (1)
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UCI(KEPA) : I410-ECN-0101-2015-510-001461914