지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 56 - 60 (5page)
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초록· 키워드
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Objectives The role of genetic polymorphisms of tumor necrosis factor-alpha (TNF-α) for lung cancer development was evaluated.
Methods Genotypes of the TNF-α polymorphisms, -1210C＞T, -487A ＞G, -417A＞G, IVS1+123G＞A, and IVS3+51A＞G, were determined in 616 lung cancer cases and 616 lung cancer-free controls.
Results After adjusting for body mass index and smoking, each TNF-α genotype or haplotype composed of five TNF-α single nucleotide polymorphisms did not show an association with lung cancer risk (p ＞0.05). The statistical power was found to be 88.4%, 89.3%, 93.3%, 69.7%, and 93.9% for 1210C＞T, -487A＞G, -417A＞G, IVS1+123G＞A, and IVS3+51A＞G, respectively. Furthermore, the effects of each SNP or haplotype on lung cancer risk were not found to be different according to the cell type of lung cancer (p ＞0.05). In the repeated analysis with only subjects without other diseases related to inflammation, there was also no association between polymorphisms or haplotypes of the TNF-α gene and lung cancer risk (p ＞0.05).
Conclusions This study found no association between common variants of the TNF-α gene and lung cancer risk.
Methods Genotypes of the TNF-α polymorphisms, -1210C＞T, -487A ＞G, -417A＞G, IVS1+123G＞A, and IVS3+51A＞G, were determined in 616 lung cancer cases and 616 lung cancer-free controls.
Results After adjusting for body mass index and smoking, each TNF-α genotype or haplotype composed of five TNF-α single nucleotide polymorphisms did not show an association with lung cancer risk (p ＞0.05). The statistical power was found to be 88.4%, 89.3%, 93.3%, 69.7%, and 93.9% for 1210C＞T, -487A＞G, -417A＞G, IVS1+123G＞A, and IVS3+51A＞G, respectively. Furthermore, the effects of each SNP or haplotype on lung cancer risk were not found to be different according to the cell type of lung cancer (p ＞0.05). In the repeated analysis with only subjects without other diseases related to inflammation, there was also no association between polymorphisms or haplotypes of the TNF-α gene and lung cancer risk (p ＞0.05).
Conclusions This study found no association between common variants of the TNF-α gene and lung cancer risk.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (17)
참고문헌 신청
Kaysen GA / 2004 / Inflammation: cause of vascular disease and malnutrition in dialysis patients / Semin Nephrol 24((5):431~436
Busse WW / 2001 / Asthma / N Engl J Med 344(5)):350~362
Coussens LM / 2002 / Inflammation and cancer / Nature 420(6917):860~867
Xu J / 2005 / The interaction of four genes in the inflammation pathway significantly predicts prostate cancer risk / Cancer Epidemiol Biomarkers Prev 14(11 Pt 1):2563~2568
Szlosarek PW / 2003 / Tumour necrosis factor alpha: a potential target for the therapy of solid tumours / Lancet Oncol 4(9):565~573
Busse WW / 2001 / Asthma / N Engl J Med 344(5)):350~362
Coussens LM / 2002 / Inflammation and cancer / Nature 420(6917):860~867
Xu J / 2005 / The interaction of four genes in the inflammation pathway significantly predicts prostate cancer risk / Cancer Epidemiol Biomarkers Prev 14(11 Pt 1):2563~2568
Szlosarek PW / 2003 / Tumour necrosis factor alpha: a potential target for the therapy of solid tumours / Lancet Oncol 4(9):565~573
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UCI(KEPA) : I410-ECN-0101-2015-530-001447458