지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.86 No.5
- 발행연도
- 2014.5
- 수록면
- 256 - 263 (8page)
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초록· 키워드
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Purpose: HBsAg-positive kidney recipients are at increased risk for mortality and graft failure. The aims of this study were to identify the outcomes of HBsAg-positive recipients who received preemptive antiviral agents after successful kidney transplantation and to analyze risk factors for HBV reactivation.
Methods: We retrospectively reviewed the medical records of 944 patients performed kidney transplantation between 1999 and 2010.
Results: HBsAg-negative recipients were 902 patients and HBsAg-positive recipients, 42. Among HBsAg-positive recipients, HBV reactivation was detected in 7 patients and well controlled by switch or combination therapy. Graft failure developed in only one patient due to chronic rejection regardless of HBV reactivation but no deaths occurred. All patients were alive at the end of follow-up and none developed end-stage liver disease or hepatocellular carcinoma. There was statistically significant difference in graft survival between HBsAg-positive recipients and HBsAg-negative. Multivariate analysis identified increased HBV DNA levels (>5 × 10<SUP>4</SUP> IU/mL) in the HBsAg-positive kidney transplant recipients as a risk factor for HBV reactivation (P = 0.007).
Conclusion: Effective viral suppression with antiviral agents in HBsAg-positive renal transplant recipients improves patient outcome and allograft survival. Antiviral therapy may be especially beneficial in patients with high HBV DNA levels prior to transplantation.
Methods: We retrospectively reviewed the medical records of 944 patients performed kidney transplantation between 1999 and 2010.
Results: HBsAg-negative recipients were 902 patients and HBsAg-positive recipients, 42. Among HBsAg-positive recipients, HBV reactivation was detected in 7 patients and well controlled by switch or combination therapy. Graft failure developed in only one patient due to chronic rejection regardless of HBV reactivation but no deaths occurred. All patients were alive at the end of follow-up and none developed end-stage liver disease or hepatocellular carcinoma. There was statistically significant difference in graft survival between HBsAg-positive recipients and HBsAg-negative. Multivariate analysis identified increased HBV DNA levels (>5 × 10<SUP>4</SUP> IU/mL) in the HBsAg-positive kidney transplant recipients as a risk factor for HBV reactivation (P = 0.007).
Conclusion: Effective viral suppression with antiviral agents in HBsAg-positive renal transplant recipients improves patient outcome and allograft survival. Antiviral therapy may be especially beneficial in patients with high HBV DNA levels prior to transplantation.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Korean Association for the Study of the Liver. / 2012 / KASL Clinical Practice Guidelines : management of chronic hepatitis B / Clin Mol Hepatol 18 : 109 ~ 162
2. [학술지(정기간행물)] - Kalia H. / 2011 / Hepatitis B virus and renal transplantation / Transplant Rev(Orlando) 25 : 102 ~ 109
3. [학술지(정기간행물)] - Ivanyi B. / 2008 / A primer on recurrent and de novo glomerulonephritis in renal allografts / Nat Clin Pract Nephrol 4 : 446 ~ 457
4. [학술지(정기간행물)] - Aroldi A. / 2005 / Natural history of hepatitis B and C in renal allograft recipients / Transplantation 79 : 1132 ~ 1136
5. [학술지(정기간행물)] - Fabrizi F. / 2005 / HBsAg seropositive status and survival after renal transplantation : metaanalysis of observational studies / Am J Transplant 5 : 2913 ~ 2921
2. [학술지(정기간행물)] - Kalia H. / 2011 / Hepatitis B virus and renal transplantation / Transplant Rev(Orlando) 25 : 102 ~ 109
3. [학술지(정기간행물)] - Ivanyi B. / 2008 / A primer on recurrent and de novo glomerulonephritis in renal allografts / Nat Clin Pract Nephrol 4 : 446 ~ 457
4. [학술지(정기간행물)] - Aroldi A. / 2005 / Natural history of hepatitis B and C in renal allograft recipients / Transplantation 79 : 1132 ~ 1136
5. [학술지(정기간행물)] - Fabrizi F. / 2005 / HBsAg seropositive status and survival after renal transplantation : metaanalysis of observational studies / Am J Transplant 5 : 2913 ~ 2921
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