지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.6
- 수록면
- 99 - 107 (9page)
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초록· 키워드
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Melamine-induced nephrotoxicity is closely associated with crystal formation in the kidney caused by combined exposure to melamine (Mel) and cyanuric acid (CA). However, there are few dosage-finding studies for toxicological evaluation of chronic co-exposure to Mel and CA. The objective of this study was to investigate the possible mechanism by which a Mel and CA mixture lead to renal toxicity in rats. Mel and CA were co-administered to rats via oral gavage for 50 days. Nephrotoxicity was determined by measuring blood urea nitrogen (BUN) and serum creatinine (sCr) levels. Relative kidney weights were significantly increased in rats after co-exposure to Mel+CA (63/6.3 or 630/6.3 mg/kg) mixtures. BUN and sCr levels were significantly increased after Mel and CA co-exposure. Taken together, significant increase in KIM-1, NGAL, and calbindin levels were observed in the urine of rats exposed to Mel+CA (63/6.3 or 630/6.3 mg/kg) compared with the corresponding control group. Histological analysis revealed epithelial degeneration and necrotic cell death in the proximal tubules of the kidney after co-exposure to Mel+CA (63/6.3 or 630/6.3 mg/kg). Our data suggest that Mel-mediated renal toxicity may be influenced by CA concentrations in Mel-contaminated milk or foods.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (3)
참고문헌 신청
Dongsun Park, Jeong Hee Jeon, Sunhee Shin, Seong Soo Joo, Byeongwoo Ahn, Kil-Soo Kim, Yun-Bae Kim. Increased Nephrotoxicity after Combined Administration of Melamine and Cyanuric Acid in Rats. 한국실험동물학회 학술발표대회 논문집. 2009
Dongsun Park, Tae Kyun Kim, Young Jin Choi, Sun Hee Lee, Dae-Kwon Bae, Goeun Yang, Yun-Hui Yang, Seong Soo Joo, Ehn-Kyoung Choi, Byeongwoo Ahn, Jong-Choon Kim, Kil-Soo Kim, Yun-Bae Kim. Increased Nephrotoxicity after Combined Administration of Melamine and Cyanuric Acid in Rats. Laboratory Animal Research. 2011
Jiyeon Son, Yoonjong Kang, Kyeongseok Kim, Eunbin Kim, Hyungsik Kim. Evaluation of metabolomic profiling against nephrotoxicity in Sprague-Dawley rats treated with melamine and cyanuric acid. 환경독성보건학회 심포지엄 및 학술대회. 2014
Dongsun Park, Tae Kyun Kim, Young Jin Choi, Sun Hee Lee, Dae-Kwon Bae, Goeun Yang, Yun-Hui Yang, Seong Soo Joo, Ehn-Kyoung Choi, Byeongwoo Ahn, Jong-Choon Kim, Kil-Soo Kim, Yun-Bae Kim. Increased Nephrotoxicity after Combined Administration of Melamine and Cyanuric Acid in Rats. Laboratory Animal Research. 2011
Jiyeon Son, Yoonjong Kang, Kyeongseok Kim, Eunbin Kim, Hyungsik Kim. Evaluation of metabolomic profiling against nephrotoxicity in Sprague-Dawley rats treated with melamine and cyanuric acid. 환경독성보건학회 심포지엄 및 학술대회. 2014
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UCI(KEPA) : I410-ECN-0101-2015-510-001705022