지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.6
- 수록면
- 45 - 53 (9page)
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초록· 키워드
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Pig pancreas may be a therapeutic resource for human diabetic patients. However, this potential is hindered by a lack of knowledge of the molecular events of pig pancreas development. In this study, the embryonic day 60, neonate and 6-month protein profiles of pig pancreas were ascertained at using twodimensional gel electrophoresis and matrix assisted laser desorption/ionization-time of flight mass spectrometry. Twenty four proteins were differentially expressed during pig pancreas development. Among them, 12 spots increased and 7 spots decreased according to development. The expression of 5 protein were highest at birth. Expression of digestive enzymes including trypsin, pancreatic triacylglycerol lipase and pancreatic alpha-amylase was elevated in adults, whereas chymotrypsins were highly expressed in neonates. Proteins that were abundantly expressed during gestation were alpha-1-antitrypsin, alphafetoprotein and transferrins. Taken together, we found out that several proteins were significantly up- or down- regulated from pig pancreas based on developmental stage. This study will provide basis for understanding development of pig pancreas.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (50)
참고문헌 신청
1. [학술지(정기간행물)] - Rao MS. / 2005 / Pancreatic stem cells : differentiation options / Stem Cell Rev 1 (3) : 265 ~ 271
2. [학술지(정기간행물)] - Portela-Gomes GM1. / 2004 / Neuroendocrine cell markers for pancreatic islets and tumors / Appl Immunohistochem Mol Morphol 12 (3) : 183 ~ 192
3. [학술지(정기간행물)] - Wild S. / 2004 / Global prevalence of diabetes : estimates for the year 2000 and projections for 2030 / Diabetes Care 27 (5) : 1047 ~ 1053
4. [학술지(정기간행물)] - Herber S. / 2001 / Two-dimensional analysis of tear protein patterns of diabetic patients / Electrophoresis 22 (9) : 1838 ~ 1844
5. [학술지(정기간행물)] - Sabek OM. / 2006 / Examination of gene expression profile of functional human pancreatic islets after 2-week culture / Transplant Proc 38 (10) : 3678 ~ 3679
2. [학술지(정기간행물)] - Portela-Gomes GM1. / 2004 / Neuroendocrine cell markers for pancreatic islets and tumors / Appl Immunohistochem Mol Morphol 12 (3) : 183 ~ 192
3. [학술지(정기간행물)] - Wild S. / 2004 / Global prevalence of diabetes : estimates for the year 2000 and projections for 2030 / Diabetes Care 27 (5) : 1047 ~ 1053
4. [학술지(정기간행물)] - Herber S. / 2001 / Two-dimensional analysis of tear protein patterns of diabetic patients / Electrophoresis 22 (9) : 1838 ~ 1844
5. [학술지(정기간행물)] - Sabek OM. / 2006 / Examination of gene expression profile of functional human pancreatic islets after 2-week culture / Transplant Proc 38 (10) : 3678 ~ 3679
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UCI(KEPA) : I410-ECN-0101-2015-500-001679189