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논문 기본 정보

자료유형
학술저널
저자정보
Ji Ye Ahn (Seoul National University) Il Yong Kim (Seoul National University) Sae Jin Oh (Seoul National University) Hye Sook Hwang (Seoul National University) Sun Shin Yi (Soonchunhyang University) Yo Na Kim (Seoul National University) Jae Hoon Shin (Seoul National University) Yeo Sung Yoon (Seoul National University) Je Kyung Seong (Seoul National University)
저널정보
한국실험동물학회 Laboratory Animal Research Laboratory Animal Research Vol.30 No.2
발행연도
2014.6
수록면
45 - 53 (9page)

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초록· 키워드

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Pig pancreas may be a therapeutic resource for human diabetic patients. However, this potential is hindered by a lack of knowledge of the molecular events of pig pancreas development. In this study, the embryonic day 60, neonate and 6-month protein profiles of pig pancreas were ascertained at using twodimensional gel electrophoresis and matrix assisted laser desorption/ionization-time of flight mass spectrometry. Twenty four proteins were differentially expressed during pig pancreas development. Among them, 12 spots increased and 7 spots decreased according to development. The expression of 5 protein were highest at birth. Expression of digestive enzymes including trypsin, pancreatic triacylglycerol lipase and pancreatic alpha-amylase was elevated in adults, whereas chymotrypsins were highly expressed in neonates. Proteins that were abundantly expressed during gestation were alpha-1-antitrypsin, alphafetoprotein and transferrins. Taken together, we found out that several proteins were significantly up- or down- regulated from pig pancreas based on developmental stage. This study will provide basis for understanding development of pig pancreas.

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