지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.87 No.1
- 발행연도
- 2014.6
- 수록면
- 14 - 21 (8page)
이용수
이 논문의 연구 히스토리 (3)
2012
Histopathologic Factors Affecting Tumor Recurrence after Hepatic Resection in Colorectal Liver Metastases
Min-Su Pa
,
k
,
Nam-Joon Yi
외 7명
한국간담췌외과학회 학술대회지
2012.04
학술대회자료
Histopathologic Factors affecting tumor recurrence after hepatic resection in Colorectal Liver Metastases
Min-Su Pa
,
k
,
Nam-Joon Yi
외 6명
대한임상종양학회 학술대회지
2012.03
학술대회자료
- 이 논문의 후속연구가 궁금하신가요?
- 연관 학술논문 또는 학술발표를 통해 보다 발전된 연구결과를 확인하실 수 있습니다.
- 이 논문의 연구 히스토리 확인하기
초록· 키워드
오류제보하기
Purpose: Hepatic resection is a standard method of treatment for colorectal liver metastases (CRLM). However, the pathologic factors of metastatic lesions that affect tumor recurrence are less well defined in CRLM. The aim of this study was to evaluate the risk factors for recurrence of CRLM, focusing on histopathologic factors of metastatic lesions of the liver.
Methods: From January 2003 to December 2008, 117 patients underwent curative hepatic resection for CRLM were reviewed. Tumor size and number, differentiation, tumor budding, angio-invasion, dedifferentiation and tumor infiltrating inflammation of metastatic lesions were investigated.
Results: The mean number of hepatic tumors was 2 (range, 1?8). The mean size of the largest tumor was 2.9 cm (range, 0.3?18.5 cm) in diameter. The moderate differentiation of the hepatic tumor was the most common in 86.3% of the patients. Tumor budding, angio-invasion, and dedifferentiation were observed in 81%, 34%, and 12.8% of patients. Inflammation infiltrating tumor was detected in 6.8% of patients. Recurrence after hepatic resection appeared in 69 out of 117 cases (58.9%). Recurrence-free survival at 1, 2 and 5 years were 62.4%, 43.6%, and 34.3%. The multivariate analysis showed the number of metastases ≥3 (P = 0.007), the tumor infiltrating inflammation (P = 0.047), and presence of dedifferentiation (P = 0.020) to be independent risk factors for tumor recurrence.
Conclusion: Histopathological factors, i.e., dedifferentiation and tumor infiltrating inflammation of the metastatic lesion, could be one of the risk factors of aggressive behavior as well as the number of metastases even after curative resection for CRLM.
Methods: From January 2003 to December 2008, 117 patients underwent curative hepatic resection for CRLM were reviewed. Tumor size and number, differentiation, tumor budding, angio-invasion, dedifferentiation and tumor infiltrating inflammation of metastatic lesions were investigated.
Results: The mean number of hepatic tumors was 2 (range, 1?8). The mean size of the largest tumor was 2.9 cm (range, 0.3?18.5 cm) in diameter. The moderate differentiation of the hepatic tumor was the most common in 86.3% of the patients. Tumor budding, angio-invasion, and dedifferentiation were observed in 81%, 34%, and 12.8% of patients. Inflammation infiltrating tumor was detected in 6.8% of patients. Recurrence after hepatic resection appeared in 69 out of 117 cases (58.9%). Recurrence-free survival at 1, 2 and 5 years were 62.4%, 43.6%, and 34.3%. The multivariate analysis showed the number of metastases ≥3 (P = 0.007), the tumor infiltrating inflammation (P = 0.047), and presence of dedifferentiation (P = 0.020) to be independent risk factors for tumor recurrence.
Conclusion: Histopathological factors, i.e., dedifferentiation and tumor infiltrating inflammation of the metastatic lesion, could be one of the risk factors of aggressive behavior as well as the number of metastases even after curative resection for CRLM.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (17)
참고문헌 신청
1. [학술지(정기간행물)] - Choti MA. / 2002 / Trends in long-term survival following liver resection for hepatic colorectal metastases / Ann Surg 235 : 759 ~ 766
2. [학술지(정기간행물)] - Tomlinson JS. / 2007 / Actual 10-year survival after resection of colorectal liver metastases defines cure / J Clin Oncol 25 : 4575 ~ 4580
3. [학술지(정기간행물)] - Yamamoto J. / 1999 / Factors influencing survival of patients undergoing hepatectomy for colorectal metastases / Br J Surg 86 : 332 ~ 337
4. [학술지(정기간행물)] - Yokoi Y. / 2002 / The impact of hepatic resection on metastatic colorectal cancer / Gan To Kagaku Ryoho 29 : 848 ~ 855
5. [학술지(정기간행물)] - Malafosse R. / 2001 / Surgical management of hepatic metastases from colorectal malignancies / Ann Oncol 12 : 887 ~ 894
2. [학술지(정기간행물)] - Tomlinson JS. / 2007 / Actual 10-year survival after resection of colorectal liver metastases defines cure / J Clin Oncol 25 : 4575 ~ 4580
3. [학술지(정기간행물)] - Yamamoto J. / 1999 / Factors influencing survival of patients undergoing hepatectomy for colorectal metastases / Br J Surg 86 : 332 ~ 337
4. [학술지(정기간행물)] - Yokoi Y. / 2002 / The impact of hepatic resection on metastatic colorectal cancer / Gan To Kagaku Ryoho 29 : 848 ~ 855
5. [학술지(정기간행물)] - Malafosse R. / 2001 / Surgical management of hepatic metastases from colorectal malignancies / Ann Oncol 12 : 887 ~ 894
이 논문의 저자 정보
최근 본 자료
댓글(0)
0