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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.8
- 수록면
- 429 - 433 (5page)
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초록· 키워드
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To identify sequences of Entamoeba histolytica associated with the development of amebic liver abscess (ALA) in hamsters, subtractive hybridization of cDNA from E. histolytica HM-1:IMSS under 2 growth conditions was performed: 1) cultured in axenic medium and 2) isolated from experimental ALA in hamsters. For this procedure, 6 sequences were obtained. Of these sequences, the mak16 gene was selected for amplification in 29 cultures of E. histolytica isolated from the feces of 10 patients with intestinal symptoms and 19 asymptomatic patients. Only 5 of the 10 isolates obtained from symptomatic patients developed ALA and amplified the mak16 gene, whereas the 19 isolates from asymptomatic patients did not amplify the mak16 gene nor did they develop ALA. Based on the results of Fisher’s exact test (P<0.001), an association was inferred between the presence of the mak16 gene of E. histolytica and the ability to develop ALA in hamsters and with the patient’s symptoms (P=0.02). The amplification of the mak16 gene suggests that it is an important gene in E. histolytica because it was present in the isolates from hamsters that developed liver damage.
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참고문헌 (25)
참고문헌 신청
Walsh JA / 1986 / Problems in recognition and diagnosis of amebiasis : estimation of the global magnitude of morbidity and mortality / Rev Infect Dis 8:228~238
Espinosa-Cantellano M / 2000 / Pathogenesis of intestinal amebiasis : from molecules to disease / Clin Microbiol Rev 13:318~331
Santi-Rocca J / 2009 / Host-microbe interactions and defense mechanisms in the development of amoebic liver abscesses / Clin Microbiol Rev 22:65~75
Weber C / 2006 / Stress by heat shock induces massive down regulation of genes and allows differential allelic expression of the Gal/GalNAc lectin in Entamoeba histolytica / Eukaryot Cell 5:871~875
Gilchrist CA / 2009 / Using differential gene expression to study Entamoeba histolytica pathogenesis / Trends Parasitol 25:124~131
Espinosa-Cantellano M / 2000 / Pathogenesis of intestinal amebiasis : from molecules to disease / Clin Microbiol Rev 13:318~331
Santi-Rocca J / 2009 / Host-microbe interactions and defense mechanisms in the development of amoebic liver abscesses / Clin Microbiol Rev 22:65~75
Weber C / 2006 / Stress by heat shock induces massive down regulation of genes and allows differential allelic expression of the Gal/GalNAc lectin in Entamoeba histolytica / Eukaryot Cell 5:871~875
Gilchrist CA / 2009 / Using differential gene expression to study Entamoeba histolytica pathogenesis / Trends Parasitol 25:124~131
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UCI(KEPA) : I410-ECN-0101-2015-510-002710472