지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.9
- 수록면
- 123 - 130 (8page)
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초록· 키워드
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Endocrine-disrupting chemicals (EDCs) are exogenous substances that alter the structure or function of the endocrine system. 4-Tert-octylphenol (OP) is one of the most representative EDCs and has estrogenic effects. In this study, we examined the effects of ethinyl estradiol (EE) and OP on the pituitary gland, placenta, and uterus of pregnant rats. Expression levels of human chorionic gonadotropin (hCG), oxytocin (OT), and contraction-associated proteins (CAPs) were determined, and uterine contractile activity was measured by uterine contraction assay. EE and OP both increased mRNA expression of OT and hCG in the pituitary gland but not the placenta. Since OT and hCG control uterine contraction, we next examined CAP expression in the uterus. Expression of 15-hydroxyprostaglandin-dehydrogenase (PGDH) was upregulated by OP, whereas expression of other CAPs was unaffected. To clarify the effect of OP on uterine contraction in pregnant rats, uterine contraction assay was performed. The 17β-Estradiol (E2) did not affect contraction of primary uterine cells harvested from pregnant rats in a 3D collagen gel model. However, OP showed different effects from E2 by significantly reducing contraction activity. In summary, we demonstrated that OP interferes with regulation of OT and hCG in the pituitary gland as well as PGDH in the uterus, thereby reducing uterine contraction activity. This result differs from the action of endogenous E2. Collectively, these findings suggest that exposure to EDCs such as OP during pregnancycan reduce uterine contractile ability, which may result in contraction-associated adverse effects such as metratonia, bradytocia, and uterine leiomyomata.
목차
Materials and Methods
Results
Discussion
References
참고문헌 (39)
참고문헌 신청
1. [학술지(정기간행물)] - Nilsson R. / 2000 / Endocrine modulators in the food chain and environment / Toxicol Pathol 28 (3) : 420 ~ 431
2. [학술지(정기간행물)] - Rudel RA. / 2009 / Endocrine disrupting chemicals in indoor and outdoor air / Atmos Environ 43 (1) : 170 ~ 181
3. [학술지(정기간행물)] - White R. / 1994 / Environmentally persistent alkylphenolic compounds are estrogenic / Endocrinology 135 (1) : 175 ~ 182
4. [학술지(정기간행물)] - An BS. / 2013 / QEffects of estrogen and estrogenic compounds, 4-tertoctylphenol, and bisphenol A on the uterine contraction and contraction-associated proteins in rats / Mol Cell Endocrinol 375 (1-2) : 27 ~ 34
5. [학술지(정기간행물)] - Kota SK. / 2013 / Endocrinology of parturition / Indian J Endocrinol Metab 17 (1) : 50 ~ 59
2. [학술지(정기간행물)] - Rudel RA. / 2009 / Endocrine disrupting chemicals in indoor and outdoor air / Atmos Environ 43 (1) : 170 ~ 181
3. [학술지(정기간행물)] - White R. / 1994 / Environmentally persistent alkylphenolic compounds are estrogenic / Endocrinology 135 (1) : 175 ~ 182
4. [학술지(정기간행물)] - An BS. / 2013 / QEffects of estrogen and estrogenic compounds, 4-tertoctylphenol, and bisphenol A on the uterine contraction and contraction-associated proteins in rats / Mol Cell Endocrinol 375 (1-2) : 27 ~ 34
5. [학술지(정기간행물)] - Kota SK. / 2013 / Endocrinology of parturition / Indian J Endocrinol Metab 17 (1) : 50 ~ 59
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