지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.87 No.4
- 발행연도
- 2014.9
- 수록면
- 174 - 179 (6page)
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초록· 키워드
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Purpose: The primary aim of the present study was to analyze the association between high-risk clinicopathologic characteristics and the BRAFV600E mutation.
Methods: From March 2010 to September 2012, we performed analysis of the BRAF mutation (assessing V600E point mutation of BRAF gene, exon 15, on chromosome 7q34 by real-time polymerase chain reaction kit) from 499 papillary thyroid carcinoma (PTC) patients who underwent thyroidectomy. We analyzed the relation between the mutation and known clinicopathologic risk factors of PTC.
Results: BRAF mutations were found in 353 of 499 patients (70.7%). On univariate analysis, BRAF mutations were more frequently detected in patients with central lymph node metastasis (78.5% vs. 66.7%, P = 0.007) and classic PTC type (71.3% vs. 16.7%, P = 0.011). Patients with one or more aggressive pathologic feature such as lymph node metastasis, multifocality, and extrathyroidal extension showed higher BRAF mutation rate (73.5% vs. 62.3%, P = 0.022). BRAF mutation group showed more aggressive pathologic features, which is considered as higher necessity of radioactive iodine ablation (relative risk, 1.617; P = 0.035).
Conclusion: This study found that BRAF mutation is associated with classic PTC and central lymph node metastasis and higher necessity of radioactive iodine ablation.
Methods: From March 2010 to September 2012, we performed analysis of the BRAF mutation (assessing V600E point mutation of BRAF gene, exon 15, on chromosome 7q34 by real-time polymerase chain reaction kit) from 499 papillary thyroid carcinoma (PTC) patients who underwent thyroidectomy. We analyzed the relation between the mutation and known clinicopathologic risk factors of PTC.
Results: BRAF mutations were found in 353 of 499 patients (70.7%). On univariate analysis, BRAF mutations were more frequently detected in patients with central lymph node metastasis (78.5% vs. 66.7%, P = 0.007) and classic PTC type (71.3% vs. 16.7%, P = 0.011). Patients with one or more aggressive pathologic feature such as lymph node metastasis, multifocality, and extrathyroidal extension showed higher BRAF mutation rate (73.5% vs. 62.3%, P = 0.022). BRAF mutation group showed more aggressive pathologic features, which is considered as higher necessity of radioactive iodine ablation (relative risk, 1.617; P = 0.035).
Conclusion: This study found that BRAF mutation is associated with classic PTC and central lymph node metastasis and higher necessity of radioactive iodine ablation.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Davies L. / 2006 / Increasing incidence of thyroid cancer in the United States, 1973-2002 / JAMA 295 : 2164 ~ 2167
2. [인터넷자원] - / / National Cancer Information Center
3. [인터넷자원] - / / Previous version: SEER cancer statistics review, 1975-2009 (vintage 2009 populations)
4. [학술지(정기간행물)] - Di Benedetto G. / 2013 / BRAF test and cytological diagnosis with a single fine needle cytology sample / Acta Cytol 57 : 337 ~ 340
5. [학술지(정기간행물)] - Davies H. / 2002 / Mutations of the BRAF gene in human cancer / Nature 417 : 949 ~ 954
2. [인터넷자원] - / / National Cancer Information Center
3. [인터넷자원] - / / Previous version: SEER cancer statistics review, 1975-2009 (vintage 2009 populations)
4. [학술지(정기간행물)] - Di Benedetto G. / 2013 / BRAF test and cytological diagnosis with a single fine needle cytology sample / Acta Cytol 57 : 337 ~ 340
5. [학술지(정기간행물)] - Davies H. / 2002 / Mutations of the BRAF gene in human cancer / Nature 417 : 949 ~ 954
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UCI(KEPA) : I410-ECN-0101-2015-510-002857710