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논문 기본 정보

자료유형
학술저널
저자정보
Joon Ho Moon (Seoul National University) Dae Young Yoo (Seoul National University) Young Kwang Jo (Seoul National University) Geon A Kim (Seoul National University) Hyo Young Jung (Seoul National University) Jung Hoon Choi (Kangwon National University) In Koo Hwang (Seoul National University) Goo Jang (Seoul National University)
저널정보
한국실험동물학회 Laboratory Animal Research Laboratory Animal Research Vol.30 No.4
발행연도
2014.12
수록면
185 - 189 (5page)

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초록· 키워드

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Cryptorchidism is one of the most common genital defects in dogs. This study investigated the effects of abdominal cryptorchidism on morphology, cell proliferation, and Sertoli cell condition in a dog with spontaneous unilateral cryptorchidism. Elective orchidectomy was performed on the abdominal right testis and the scrotal left testis. Significant reductions in numbers of spermatogonia, spermatocytes, and spermatids were observed in hematoxylin and eosin stained sections of the cryptorchid testis. The size of the epididymal duct was smaller than that of the control testis. Based on Ki67 immunohistochemistry, the proliferative activity of spermatogonia and spermatocytes was significantly decreased in the cryptorchid testis. However, proliferative activity was increased in the epididymal duct. Based on GATA-4 immunohistochemistry, Sertoli cells were relatively resistant to cryptorchidism, and the proliferative activity of Sertoli cells was markedly increased in the cryptorchid testis than in the control testis. These results suggest that spontaneous unilateral cryptorchidism causes morphological defects in spermatogonia and spermatocytes in the testis and changes the size of the efferent ductule of the epididymis. In addition, spontaneous unilateral cryptorchidism increases proliferative activity of Sertoli cells, which may be a predisposing factor for Sertoli cell cancer in cryptorchid testes.

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UCI(KEPA) : I410-ECN-0101-2016-528-001001850