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논문 기본 정보

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학술저널
저자정보
Jung-Min Lee (Biotoxtech) Young-Hwan Han (Biotoxtech) Su-Jeong Choi (Biotoxtech) Ju-seong Park (Biotoxtech) Jeong-Jun Jang (Biotoxtech) Re-Ji-Na Bae (Biotoxtech) Mi Ju Lee (Biotoxtech) Myoung Jun Kim (Biotoxtech) Yong-Hoon Lee (Biotoxtech) Duyeol Kim (Biotoxtech) Hye-Young Lee (Biotoxtech) Sun-Hee Park (Biotoxtech) Cheol-Beom Park (Biotoxtech) Jin Seok Kang (Namseoul University) Jong-Koo Kang (Chungbuk National University)
저널정보
한국독성학회 Toxicological Research Toxicological Research Vol.30 No.4
발행연도
2014.12
수록면
305 - 309 (5page)

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Recently, there has been an increase in the use of several nephrotoxicity biomarkers in preclinical experiments. In addition, it has been indicated that the result may have been influenced by secondary factors, such as sample storage condition or storage period. In this study, we have assessed the variation in urinary nephrotoxicity biomarkers as a result of urine storage conditions and storage period of the urine. Urine was sampled from specific pathogen-free Sprague-Dawley rats (19 weeks old), which were housed individually in hanged stainless steel wire mesh cages. Urine was stored at 20℃, at 4℃, or at ?70℃ after sampling. The levels of the biomarkers such as beta-2 microglobulin (B2M), cystatin-C (Cys-C), N-acetyl-β-D-glucosaminidase (NAG), micro albumin (MA), micro protein (MP) were measured at 6, 24, 48 and 144 hr after sampling. The B2M level was significantly decreased at 6, 24, 48, and 144 hr compared to 0 hr at ?70℃ (p < 0.05, p < 0.01, p < 0.05, and p < 0.05, respectively) and 24 and 144 hr at 20℃ (p < 0.01, p < 0.01, respectively). The Cys-C level was significantly decreased at 144 hr compared to 0 hr at 4℃ (p < 0.01), at 20℃ (p < 0.05) and at 70℃ (p < 0.01). MP and MA levels were not different for 144 hr in all storage conditions. Taken together, B2M and Cys-C levels were modulated by storage temperature and period. For the enhancement of test accuracy, it is suggested that strict protocols be established for samples to minimize the effects of the storage conditions on the detected levels of biomarkers.
#Nephrotoxicity #Biomarkers #Storage temperature #Storage period #Stability

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INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISSCUSSION
REFERENCES

참고문헌 (20)

참고문헌 신청
Dieterle, F. / 2010 / Urinary clusterin, cystatin C, beta2-microglobulin and total protein as markers to detect drug-induced kidney injury / Nat. Biotechnol 28:463~469 google schola Vaidya, V. S. / 2008 / Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans / Clin. Transl. Sci 1:200~208 google schola Belcher, J. M. / 2011 / Clinical applications of biomarkers for acute kidney injury / Am. J. Kidney Dis 57:930~940 google schola Waikar, S.S. / 2008 / Biomarkers for the diagnosis of acute kidney injury / Nephron Clin. Pract 109:c192~c197 google schola Sun Young Kim / 2012 / Drug-Induced Nephrotoxicity and Its Biomarkers / Biomolecules & Therapeutics 20(3):268~272 google schola

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