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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.8
- 수록면
- 390 - 395 (6page)
- DOI
- 10.15188/kjopp.2014.08.28.4.390
이용수
초록· 키워드
오류제보하기
Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Listeria. monocytogenes and Bacillus cereus are pathogenic bacteria that should not be detected in cosmetics and foodstuffs. Therefore, we first investigated the antimicrobial activities of extracts of Scutellariae Radix(SR), Coptidis Rhizoma (CR) and salicylic acid(SA) in these pathogenic microorganisms. Although SA has been known to exhibit anti-inflammation and antimicrobial activity against pathogenic microorganisms, a high concentration of SA may cause serious side effects such as skin redness, skin burning, peeling or tissue damage. Hence, we focused on diminishing side effects followed by treatment of a high concentration of SA and investigated whether the combinations of SA with various concentrations(25-400 ㎎/mL), SR and CR with a concentration(100 ㎎/mL) which did not show antimicrobial activity against E. coli and P. aeruginosa exhibited meaningful antimicrobial effect against both strains. In our results, the combinations of SA with the lowest concentration(25 ㎎/mL), SR(100 ㎎/mL) and CR(100 ㎎/mL) exhibited significant antimicrobial activity against E.coli in comparison to SA alone(25 ㎎/mL) showing no antimicrobial activity. Moreover, the combinations of SA (100 ㎎/mL), SR and CR showed seven times higher antimicrobial activity against E. coli than SA alone(100 ㎎/mL) and exhibited a significant antimicrobial activity in comparison to ampicilin (p＜0.05). The combinations of SA(100 ㎎/mL), SR and CR showed two times higher antimicrobial activity against P. aeruginosa than SA alone. Therefore, these results indicated that the combinations of SR, CR and SA with low concentration expressed the synergistic antimicrobial effect against E. coli and P. aeruginosa and showed great potential as an antimicrobial agent.
목차
서론
재료 및 방법
결과
고찰
결론
References
참고문헌 (20)
참고문헌 신청
1. [보고서] - 김성조 / 2006 / 홍성삼, 이철수, 식중독 예방사업 중장기 계획 연구 : 8 ~ 12
2. [보고서] - 윤기선 / 2010 / 식중독균 미생물의 위해평가를 위한 종합계획 및 예측모델링 개발 : 14 ~ 16
3. [학술지(정기간행물)] - de Oliveira, C. S. / 2012 / Synthetic approaches and pharmacological activity of 1,3,4-oxadiazoles: a review of the literature from 2000-2012 / Molecules 17 : 10192 ~ 10231
4. [학술지(정기간행물)] - Alekshun, M. N. / 2007 / Molecular mechanisms of antibacterial multidrug resistance / Cell 128 : 1037 ~ 1050
5. [학술지(정기간행물)] - Matsuda, S. / 1992 / Pharmacokinetic and clinical evaluation of levofloxacin in obstetrical and gynecological field / Jpn J Antibiot 45 : 285 ~ 292
2. [보고서] - 윤기선 / 2010 / 식중독균 미생물의 위해평가를 위한 종합계획 및 예측모델링 개발 : 14 ~ 16
3. [학술지(정기간행물)] - de Oliveira, C. S. / 2012 / Synthetic approaches and pharmacological activity of 1,3,4-oxadiazoles: a review of the literature from 2000-2012 / Molecules 17 : 10192 ~ 10231
4. [학술지(정기간행물)] - Alekshun, M. N. / 2007 / Molecular mechanisms of antibacterial multidrug resistance / Cell 128 : 1037 ~ 1050
5. [학술지(정기간행물)] - Matsuda, S. / 1992 / Pharmacokinetic and clinical evaluation of levofloxacin in obstetrical and gynecological field / Jpn J Antibiot 45 : 285 ~ 292
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