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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.3
- 수록면
- 10 - 16 (7page)
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Purpose: Pilocarpine has the effects on improvement of salivary flow and subjective symptoms for xerostomic patients. Because of unwanted side effects following its systemic administration, topical pilocarpine has been paid attention as an alternative. This study aimed to investigate effects of pilocarpine solution as mouthwash on salivary flow and adverse effects compared to systemic administration of 5 mg pilocarpine tablet in healthy subjects.
Methods: The study was a double blind, placebo-controlled, crossover clinical trial. Five milligrams pilocarpine tablets, 4 mL of 2% pilocarpine solution and placebo solution were given to 12 healthy volunteers (6 males and 6 females) in a predetermined order with wash-out period of at least two days and unstimulated whole saliva was collected before and after administration of each drug. Blood pressure and pulse rate was also measured and subjective effect and potential side effects were evaluated by a self-administrated questionnaire.
Results: Systemic (5 mg tablet) and topical (2% solution) use of pilocarpine significantly increased salivary flow rate in healthy subjects compared to placebo (p<0.001). In both the pilocarpine solution and tablet groups, salivary flow rates at 120 minutes after administration remained increased. Subjective effect on salivation was the largest in the pilocarpine tablet group, followed by the pilocarpine solution group (p<0.05). There was no significant difference in blood pressure and pulse rate after administration of all three drugs. Fewer side effects reported in the pilocarpine solution group than in the tablet group.
Conclusions: Two percents pilocarpine solution as mouthwash increases salivary flow rate, definitely superior to placebo solution and comparable to pilocarpine tablet, with fewer side effects in healthy subjects. It indicates a possibility of pilocarpine solution as a useful alternative of pilocarpine tablets for the xerostomic patients with systemic diseases.
Methods: The study was a double blind, placebo-controlled, crossover clinical trial. Five milligrams pilocarpine tablets, 4 mL of 2% pilocarpine solution and placebo solution were given to 12 healthy volunteers (6 males and 6 females) in a predetermined order with wash-out period of at least two days and unstimulated whole saliva was collected before and after administration of each drug. Blood pressure and pulse rate was also measured and subjective effect and potential side effects were evaluated by a self-administrated questionnaire.
Results: Systemic (5 mg tablet) and topical (2% solution) use of pilocarpine significantly increased salivary flow rate in healthy subjects compared to placebo (p<0.001). In both the pilocarpine solution and tablet groups, salivary flow rates at 120 minutes after administration remained increased. Subjective effect on salivation was the largest in the pilocarpine tablet group, followed by the pilocarpine solution group (p<0.05). There was no significant difference in blood pressure and pulse rate after administration of all three drugs. Fewer side effects reported in the pilocarpine solution group than in the tablet group.
Conclusions: Two percents pilocarpine solution as mouthwash increases salivary flow rate, definitely superior to placebo solution and comparable to pilocarpine tablet, with fewer side effects in healthy subjects. It indicates a possibility of pilocarpine solution as a useful alternative of pilocarpine tablets for the xerostomic patients with systemic diseases.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Mandel ID / 1980 / Sialochemistry in diseases and clinical situations affecting salivary glands / Crit Rev Clin Lab Sci 12 : 321 ~ 366
2. [단행본] - Sreebny LM / 1996 / Saliva and oral health / British Dental Association : 43 ~ 46
3. [학술지(정기간행물)] - Ishii M / 2006 / Muscarinic acetylcholine receptors / Curr Pharm Des 12 : 3573 ~ 3581
4. [학술지(정기간행물)] - Frydrych AM / 2002 / An investigation into the use of pilocarpine as a sialagogue in patients with radiation induced xerostomia / Aust Dent J 47 : 249 ~ 253
5. [학술지(정기간행물)] - Hamlar DD / 1996 / Determination of the efficacy of topical oral pilocarpine for postirradiation xerostomia in patients with head and neck carcinoma / Laryngoscope 106 : 972 ~ 976
2. [단행본] - Sreebny LM / 1996 / Saliva and oral health / British Dental Association : 43 ~ 46
3. [학술지(정기간행물)] - Ishii M / 2006 / Muscarinic acetylcholine receptors / Curr Pharm Des 12 : 3573 ~ 3581
4. [학술지(정기간행물)] - Frydrych AM / 2002 / An investigation into the use of pilocarpine as a sialagogue in patients with radiation induced xerostomia / Aust Dent J 47 : 249 ~ 253
5. [학술지(정기간행물)] - Hamlar DD / 1996 / Determination of the efficacy of topical oral pilocarpine for postirradiation xerostomia in patients with head and neck carcinoma / Laryngoscope 106 : 972 ~ 976
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UCI(KEPA) : I410-ECN-0101-2016-515-001358453