Effects of phylloquinone supplementation on lipid profile in women with rheumatoid arthritis : a double blind placebo controlled study :a double blind placebo controlled study

Sousan Kolahi; Bahram Pourghassem Gargari; Mehran Mesgari Abbasi; Mohammad Asghari Jafarabadi; Neda Ghamarzad Shishavan

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저자정보: Sousan Kolahi (Tabriz University of Medical Sciences) Bahram Pourghassem Gargari (Tabriz University of Medical Sciences) Mehran Mesgari Abbasi (Tabriz University of Medical Sciences) Mohammad Asghari Jafarabadi (Tabriz University of Medical Sciences) Neda Ghamarzad Shishavan (Tabriz University of Medical Sciences)

저널정보: 한국영양학회 Nutrition Research and Practice Nutrition Research and Practice Vol.9 No.2

발행연도: 2015.4

수록면: 186 - 191 (6page)

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BACKGROUND/OBJECTIVES: Rheumatoid arthritis (RA) is associated with an excess mortality from cardiovascular disease which is likely attributed to an atherogenic lipid profile. Among nutritional factors vitamin K has been recently focused as a pivotal nutrient in improvement of lipid related markers. Thus, this study was designed to determine the effects of vitamin K on lipid profile in this disease.
SUBJECTS/METHODS: Fifty eight patients with definitive RA were participated in the present double blind placebo controlled study. They were randomly allocated into two groups to receive vitamin K1 as phylloquinone [10 mg/day] (n = 30) or placebo pills (n = 28), for eight weeks. In order to control the effects of probable confounders dietary intakes, anthropometric measurements including weight and height, clinical status using disease activity score-28 (DAS-28), physical activity and anxiety status were evaluated at baseline. Moreover, serum levels of lipid related markers including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) were measured at baseline and at the end of intervention.
RESULTS: There were no significant differences between the two groups regarding any of the baseline characteristics. After adjusting for some relevant confounders, in comparison between two groups, we observed no significant changes in lipid related markers at the end of intervention. Also, there was no significant difference between before and after intervention values within groups (P > 0.05).
CONCLUSIONS: Function of vitamin K1 in lipid profile modification remains still controversial. This study showed that vitamin K1 has no effect on lipid profile in women with rheumatoid arthritis. Further studies with a longer follow-up are required to determine the effects of vitamin K on atherogenic lipid profile.

#Rheumatoid arthritis #vitamin K1 #phylloquinone #lipid profile

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