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논문 기본 정보

자료유형
학술저널
저자정보
Maria Luz Fernandez (University of Connecticut) Jennifer J Jones (University of Connecticut) Daniela Ackerman (University of Connecticut) Jacqueline Barona (University of Connecticut) Mariana Calle (University of Connecticut) Michael V Comperatore (University of Connecticut) Jung-Eun Kim (University of Connecticut) Catherine Andersen (University of Connecticut) Jose O Leite (University of Connecticut) Jeff S Volek (University of Connecticut) Mark McIntosh (University of Florida) Colleen Kalynych (University of Florida) Wadie Najm (University of California) Robert H Lerman (Gig Harbor)
저널정보
대한지역사회영양학회 Nutrition Research and Practice Nutrition Research and Practice Vol.4 No.6
발행연도
2010.12
수록면
492 - 498 (7page)

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Both metabolic syndrome (MetS) and elevated LDL cholesterol (LDL-C) increase the risk for cardiovascular disease (CVD). We hypothesized that low HDL cholesterol (HDL-C) would further increase CVD risk in women having both conditions. To assess this, we recruited 89 women with MetS (25-72 y) and LDL-C ≥ 2.6 mmol/L. To determine whether plasma HDL-C concentrations were associated with dietary components, circulating atherogenic particles, and other risk factors for CVD, we divided the subjects into two groups: high HDL-C (H-HDL) (≥ 1.3 mmol/L, n = 32) and low HDL-C (L-HDL) (< 1.3 mmol/L, n = 57). Plasma lipids, insulin, adiponectin, apolipoproteins, oxidized LDL, Lipoprotein(a), and lipoprotein size and subfractions were measured, and 3-d dietary records were used to assess macronutrient intake. Women with L-HDL had higher sugar intake and glycemic load (P < 0.05), higher plasma insulin (P < 0.01), lower adiponectin (P < 0.05), and higher numbers of atherogenic lipoproteins such as large VLDL (P < 0.01) and small LDL (P < 0.001) than the H-HDL group. Women with L-HDL also had larger VLDL and both smaller LDL and HDL particle diameters (P < 0.001). HDL-C was positively correlated with LDL size (r = 0.691, P < 0.0001) and HDL size (r = 0.606, P < 0.001), and inversely correlated with VLDL size (r = -0.327, P < 0.01). We concluded that L-HDL could be used as a marker for increased numbers of circulating atherogenic lipoproteins as well as increased insulin resistance in women who are already at risk for CVD.

목차

Abstract
Introduction
Subjects and Methods
Results
Discussion
References

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