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Effect of onion peel extract supplementation on the lipid profile and antioxidative status of healthy young women : a randomized, placebo-controlled, double-blind, crossover trial
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Type
Academic journal
Author
Jungmi Kim (Kyungnam University) Yong-Jun Cha (Changwon National University) Kyung-Hea Lee (Changwon National University) Eunju Park (Kyungnam University)
Journal
The Korean Society Of Community Nutrition Nutrition Research and Practice Vol.7 No.5 KCI Accredited Journals SCIE
Published
2013.10
Pages
373 - 379 (7page)

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Effect of onion peel extract supplementation on the lipid profile and antioxidative status of healthy young women : a randomized, placebo-controlled, double-blind, crossover trial
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The consumption of fruits and vegetables that have high polyphenol content has been previously associated with a reduced risk for cardiovascular disease. We investigated the effects of onion peel extract on plasma total antioxidant capacity, lipid peroxidation, and leukocyte DNA damage. This study was a randomized, double-blind, placebo-controlled, crossover trial. Healthy female subjects received either onion peel extract or placebo (dextrin) for two weeks, underwent a 1-week washout period, and then received the other treatment for an additional two weeks. After two weeks of onion peel extract supplementation, the total cholesterol level, low-density lipoprotein cholesterol level, and atherogenic index significantly decreased (P < 0.05). No changes were observed in activities of erythrocyte antioxidant enzymes or levels of lipid peroxidation markers following onion peel extract supplementation. Additionally, no significant difference was found in plasma antioxidant vitamin (retinol, tocopherols, carotenoids, and coenzyme Q10) levels or ex vivo H₂O₂-provoked oxidative DNA damage after onion peel extract supplementation. The present interventional study provides evidence of the health benefits of onion peel extract and demonstrates its effects in modulating lipid profiles in healthy young Korean women.
#Onion peel extract #lipid profile #antioxidant status #DNA damage #healthy young women

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