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논문 기본 정보

자료유형
학술저널
저자정보
Weiqian Zhang (Northeast Agricultural University) Yan Liu (Inner Mongolia University for Nationalities) Ming Ge (Northeast Agricultural University) Jiang Jing (Northeast Agricultural University) Yan Chen (Northeast Agricultural University) Huijie Jiang (Northeast Agricultural University) Hongxiang Yu (Northeast Agricultural University) Ning Li (Northeast Agricultural University) Zhigang Zhang (Northeast Agricultural University)
저널정보
대한지역사회영양학회 Nutrition Research and Practice Nutrition Research and Practice Vol.8 No.2
발행연도
2014.4
수록면
220 - 226 (7page)

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초록· 키워드

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BACKGROUND/OBJECTIVES: Arsenic, which causes human carcinogenicity, is ubiquitous in the environment. This study was designed to evaluate modulation of arsenic induced cancer by resveratrol, a phytoalexin found in vegetal dietary sources that has antioxidant and chemopreventive properties, in arsenic trioxide (As₂O₃)-induced Male Wistar rats.
MATERIALS/METHODS: Adult rats received 3 mg/kg As₂O3 (intravenous injection, iv.) on alternate days for 4 days. Resveratrol(8 mg/kg) was administered (iv.) 1 h before As₂O₃ treatment. The plasma and homogenization enzymes associated with oxidative stress of rat kidneys were measured, the kidneys were examined histologically and trace element contents were assessed.
RESULTS: Rats treated with As₂O₃ had significantly higher oxidative stress and kidney arsenic accumulation; however, pretreatment with resveratrol reversed these changes. In addition, prior to treatment with resveratrol resulted in lower blood urea nitrogen, creatinine and insignificant renal tubular epithelial cell necrosis. Furthermore, the presence of resveratrol preserved the selenium content (0.805 ± 0.059 μg/g) of kidneys in rats treated with As₂O₃. However, resveratrol had no effect on zinc level in the kidney relative to As₂O₃-treated groups.
CONCLUSIONS: Our data show that supplementation with resveratrol alleviated nephrotoxicity by improving antioxidant capacity and arsenic efflux. These findings suggest that resveratrol has the potential to protect against kidney damage in populations exposed to arsenic.

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INTRODUCTION
MATERIALS AND METHODS
DISCUSSION
REFERENCES

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