지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Dexamethasone, a synthetic glucocorticoid (GC), is clinically administered to woman at risk for premature labor to induce fetal lung maturation. However, exposure to repeated or excess GCs leads to intrauterine growth restriction (IUGR) and subsequently increases risk of psychiatric and cardio-metabolic diseases in later life through fetal programming mechanisms. GCs are key mediators of stress responses, therefore, maternal nutrient restriction or psychological stress during pregnancy also causes negative impacts on birth and neurodevelopment outcome of fetuses, and other congenital defects, such as craniofacial and skeletal abnormalities. In this study, to examine the effect of prenatal stress on fetal skeletal development, dexamethasone (1 mg/kg [DEX1] or 10 mg/kg [DEX10] maternal body weight per day) was administered intraperitoneally at gestational day 7.5~9.5 and the skeletons were prepared from embryos at day 18.5. Seven out of eighteen (39%) embryos treated with DEX10 showed axial skeletal abnormalities in either the T13 or L1 vertebrae. In addition, examination of the sternum revealed that xiphoid process, the protrusive triangular part of the lower end of the sternum, was bent more outward or inward in DEX group embryos. In conclusion, our findings suggest a possible link to the understanding of the effect of uterine environment to the fetal skeletal features.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (37)
참고문헌 신청
1. [학술지(정기간행물)] - Bale TL / 2011 / Sex differences in prenatal epigenetic programming of stress pathways / Stress 14 : 348 ~ 356
2. [학술지(정기간행물)] - Canalis E / 2005 / Mechanisms of glucocorticoid action in bone / Curr Osteoporos Rep 3 : 98 ~ 102
3. [학술지(정기간행물)] - Choe HK / 2011 / Maternal stress retards fetal development in mice with transcriptome-wide impact on gene expression profiles of the limb / Stress 14 : 194 ~ 204
4. [학술지(정기간행물)] - Cuffe JSM / 2011 / Sex specific changes in placental growth and MAPK following short term maternal dexamethasone exposure in the mouse / Placenta 32 : 981 ~ 989
5. [학술지(정기간행물)] - del Mar Lorente M / 2000 / Loss- and gain-of-function mutations show a polycomb group function for Ring1A inmice / Development 127 : 5093 ~ 5100
2. [학술지(정기간행물)] - Canalis E / 2005 / Mechanisms of glucocorticoid action in bone / Curr Osteoporos Rep 3 : 98 ~ 102
3. [학술지(정기간행물)] - Choe HK / 2011 / Maternal stress retards fetal development in mice with transcriptome-wide impact on gene expression profiles of the limb / Stress 14 : 194 ~ 204
4. [학술지(정기간행물)] - Cuffe JSM / 2011 / Sex specific changes in placental growth and MAPK following short term maternal dexamethasone exposure in the mouse / Placenta 32 : 981 ~ 989
5. [학술지(정기간행물)] - del Mar Lorente M / 2000 / Loss- and gain-of-function mutations show a polycomb group function for Ring1A inmice / Development 127 : 5093 ~ 5100
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UCI(KEPA) : I410-ECN-0101-2016-510-001347973