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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Soy proteins have been extensively studied because of its multiple health benefits. However, the effects of soy proteins on human cervical cancer cells are still unclear. Therefore, this study investigated the effects of soy proteins on HeLa cells and human fibroblasts by using soybean peptides (SPs). SPs selectively increased the generation of reactive oxygen species and apoptosis in HeLa cells but not in fibroblasts. In addition, SPs suppressed the migration of HeLa cells. Although the molecular mechanisms underlying the effects of SPs on human cervical cancer cells need to be investigated further, our findings provide insights on the therapeutic effects of soy protein on cervical cancer.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
[학술지(정기간행물)] - Appelt LC / 1999 / Soy induces phase II enzymes but does not inhibit dimethylbenz[a]anthracene-induced carcinogenesisin female rats / J Nutr 129 : 1820 ~ 1826
[학술지(정기간행물)] - Clark RA / 1982 / Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization / J Invest Dermatol 79 : 264 ~ 269
[학술지(정기간행물)] - Coussens LM / 2002 / Inflammation and cancer / Nature 420 : 860 ~ 867
[학술지(정기간행물)] - Djuric Z / 2001 / Effect of soy isoflavone supplementation on markers of oxidative stress in men and women / Cancer Lett 172 : 1 ~ 6
[학술지(정기간행물)] - Food and Drug Administration / 1999 / Food labeling:health claims; soy protein and coronary heart disease / Fed Regist 64 : 57700 ~ 57733
[학술지(정기간행물)] - Clark RA / 1982 / Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization / J Invest Dermatol 79 : 264 ~ 269
[학술지(정기간행물)] - Coussens LM / 2002 / Inflammation and cancer / Nature 420 : 860 ~ 867
[학술지(정기간행물)] - Djuric Z / 2001 / Effect of soy isoflavone supplementation on markers of oxidative stress in men and women / Cancer Lett 172 : 1 ~ 6
[학술지(정기간행물)] - Food and Drug Administration / 1999 / Food labeling:health claims; soy protein and coronary heart disease / Fed Regist 64 : 57700 ~ 57733
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HeLa Cells Containing a Truncated Form of DNA Polymerase Beta are More Sensitized to Alkylating Agents than to Agents Inducing Oxidative Stress
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Pseudolaric acid B inhibits PAX2 expression through Wnt signaling and induces BAX expression, therefore promoting apoptosis in HeLa cervical cancer cells
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Phytochemicals from Goniothalamus griffithii Induce Human Cancer Cell Apoptosis
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Aloe vera Inhibits Proliferation of Human Breast and Cervical Cancer Cells and Acts Synergistically with Cisplatin
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Anti-Proliferative Activity and Apoptosis Induction of an Ethanolic Extract of Boesenbergia pandurata (Roxb.) Schlecht. against HeLa and Vero Cell Lines
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Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment
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UCI(KEPA) : I410-ECN-0101-2016-510-001658728