지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 92 - 102 (11page)
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초록· 키워드
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This work aimed to study whether rice bran extract fermented with Lactobacillus plantarum (LW) promotes functional recovery and reduces cognitive impairment after ischemic brain injury. Ischemic brain injury was induced by middle cerebral artery occlusion (MCAO) in rats. Four groups were studied, namely the (1) sham, (2) vehicle, (3) donepezil, and (4) LW groups. Animals were injected with LW once a day for 7 days after middle cerebral artery occlusion. LW group showed significantly improved neurological function as compared to the vehicle group, as well as enhanced learning and memory in the Morris water maze. The LW group showed the greatest functional recovery. Moreover, the LW group showed an enhanced more survival cells anti-apoptotic effect in the cortex and neural cell densities in the hippocampal DG and CA1. In addition, this group showed enhanced expression of neurotrophic factors, antioxidant genes, and the acetylcholine receptor gene, as well as synaptophysin (SYP), Fox-3 (NeuN), doublecortin (DCX), and choline acetyltransferase (ChAT) proteins. Our findings indicate that LW treatment showed the largest effects in functional recovery and cognitive improvement after ischemic brain injury through stimulation of the acetylcholine receptor, antioxidant genes, neurotrophic factors, and expression of NeuN, SYP, DCX, and ChAT.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (32)
참고문헌 신청
[학술지(정기간행물)] - Adamu HA / 2012 / Biotransfromation of ferulic acid to 4-vinyl guaiacol by Lactobacillus farciminis 11 : 1177 ~ 1184
[학술지(정기간행물)] - 백승은 / 2014 / Neuroprotective effect of rice bran extract supplemented with ferulic acid in the rat model of ischemic brain injury / Animal Cells and Systems 18 (2) : 93 ~ 100
[학술지(정기간행물)] - Bevins RA / 2006 / Object recognition in rats and mice: a onetrial non-matching-to-sample learning task to study 'recognition memory' / Nat Protoc 1 : 1306 ~ 1311
[학술지(정기간행물)] - Block F / 1999 / Global ischemia and behavioural deficits / Prog Neurobiol 58 : 279 ~ 295
[학술지(정기간행물)] - Chen J / 2001 / Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats / Stroke 32 : 2682 ~ 2688
[학술지(정기간행물)] - 백승은 / 2014 / Neuroprotective effect of rice bran extract supplemented with ferulic acid in the rat model of ischemic brain injury / Animal Cells and Systems 18 (2) : 93 ~ 100
[학술지(정기간행물)] - Bevins RA / 2006 / Object recognition in rats and mice: a onetrial non-matching-to-sample learning task to study 'recognition memory' / Nat Protoc 1 : 1306 ~ 1311
[학술지(정기간행물)] - Block F / 1999 / Global ischemia and behavioural deficits / Prog Neurobiol 58 : 279 ~ 295
[학술지(정기간행물)] - Chen J / 2001 / Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats / Stroke 32 : 2682 ~ 2688
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UCI(KEPA) : I410-ECN-0101-2016-510-001658748