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자료유형
학술저널
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대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY 大韓바이러스學會誌 제13권 제1호
발행연도
1983.6
수록면
23 - 28 (6page)

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Korean hemorrhagic fever (KHF) was recognized for the first time in Korea in 1951 during the Korean War when it infected the United Nations troops but similar diseases to KHF had been reported in Russia, China and elsewhere. In 1976, Lee and Lee discovered a specific antigen of KHF and demonstrated that this antigen is the etiologic agent of KHF and perfected a serologic test for diagnosis of the disease in 1978. In 1980 the etiologic agent of KHF was named Hantaan virus after the Hantaan river. Very recently, close etiological relations have been shown by serologic means between KHF in Korea and hemorrhagic nephroso-nephritis in USSR, between KHF and nephropathia epidemica in Scandinavia, between KHF and epidemic hemorrhagic fever (EHF) in Japan and between KHF and EHF in China. The working group on Hemorrhagic fever with renal syndrome at a WHO meeting in Tokyo in February 1982 recommended that the above mentioned diseases with different names should be referred as Hemorrhagic Fever with Renal Syndrome (HFRS). Although there are several reports on the transmission, sensitivities of various animals and electron microscopic findings of Hantaan virus, no report was described on physicochemical properties of the virus. This is the first report on the effect of temperature and pH on the infectivity of Hantaan virus in Apodemus mice. 1. The diameter of Hantaan virus was approximately 90 nm. 2. Hantaan virus was inactivated rapidly at above 37C. The infectivity of virus, however, was slowly decreased but preserved for about one month at 4C. 3. The optimal pH for infectivity of Hantaan virus in Apodemus mice was 7. 6 but it was inactivated completely at below pH 5.0. 4. It was demonstrated that BSS with 0. 2% bovine albumin, pH 7. 2-7. 6, was the most stable diluent for the study of the infectivity of Hantaan virus.

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