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자료유형
학술저널
저자정보
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대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY 大韓바이러스學會誌 제16권 제2호
발행연도
1986.12
수록면
113 - 120 (8page)

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Hantaan virus was first isolated in 1976 from field mice, Apodemus agrarius and in 1978 from the patient of Korean hemorrhagic fever in Korea by Lee and Lee. Hemmorragic fever with renal syndrome is a major public health problem throughout most of European and Asian land mass. Although predominantly associated with rural area, it is now being reco- gnized as an urban problem and as a particular hazard to laboratory staff using rodents for biomedical research. Hantavirus is a new Genus name which includes Hantaan virus, Seoul virus, Prospect Hill virus and Puumala virus in Byunyaviridae. Since 1976 there were outbreaks of Hemorrhagic fever with renal syndrome among personnel of animal rooms of medical centers in Korea and in Japan wehere Hantavirus experiments were never done, laboratory rat infection with Hantavirus in animal rooms of six different institutes in Seoul was studied. The results are as follows: 1. The Hantaan viral antigen were demonstrated in the pulmonary tissues of 41 (22.9%) rats out of 179 laboratory rats tested. 2. The immunofluorescent antibodies against Hantaan virus were demonstrated in 64.6% (126) of sera from 195 rats in the animal rooms of six different institutes. 3. The high levels of immunofluorescent antibodies reactive with Hantaan virus were detected in 26.7% (12) of sera from 45 personnel of animal rooms of six institutes. Although all of 12 persons developed symptoms of Hemorrhagic fever with renal syndrome, they were diagnosed as influenza by clinical physicians. 4. There was no difference in susceptibility of four kinds of laboratory rats to Hantaan virus. The above results indicated for the first time that several kinds of infected laboratory rats were reservoir of Hantavirus in the animal rooms of institutes in seoul.

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