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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.3
- 수록면
- 47 - 52 (6page)
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Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are rare and fatal neurodegenerative conditions that affect both humans and animals. Although there is increased evidence that oxidative stress plays an important role in the pathogenesis of these diseases, the direct relationship between an accumulation of abnormal prion protein (PrP<SUP>Sc</SUP>) and the occurrence of oxidative stress has not been studied. In the present study, we have investigated the cellular localization of proteins modified by lipid peroxidation end products and its correlation with PrP<SUP>Sc</SUP> accumulation in the brain of mice infected with the ME7 prion strain. Intense immunostaining of malondialdehyde (MDA)- and hydroxynonenal (HNE)-modified proteins were observed in the hippocampus of prion-infected mice. In serial section study, we found that these immunoreactivities were co-localized with glial fibrillary acidic protein (GFAP)-positive astrocytes as well as with PrP<SUP>Sc</SUP>. These results clearly indicate that the heightened oxidative stress in the form of lipid peroxidation is closely associated with PrP<SUP>Sc</SUP> accumulation in astrocytes of prion-infected mice.
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재료 및 방법
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고찰
참고문헌
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Andreoletti O / 2002 / Astrocytes accumulate 4-hydroxynonenal adducts in murine scrapie and human Creutzfeldt-Jakob disease / Neurobiol Dis 11 : 386 ~ 393
2. [학술지(정기간행물)] - Bolton DC / 1982 / Identification of a protein that purifies with the scrapie prion / Science 218 : 1309 ~ 1311
3. [학술지(정기간행물)] - Campbell IL / 1994 / Activation of cerebral cytokine gene expression and its correlation with onset of reactive astrocyte and acutephase response gene expression in scrapie / J Virol 68 : 2383 ~ 2387
4. [학술지(정기간행물)] - Choi SI / 1998 / Mitochondrial dysfunction induced by oxidative stress in the brains of hamsters infected with the 263K scrapie agent / Acta Neuropathol 96 : 279 ~ 286
5. [학술지(정기간행물)] - Choi YG / 2004 / Nonenzymatic glycation at the N terminus of pathogenic prion protein in transmissible spongiform encephalopathies / J Biol Chem 279 : 30402 ~ 30409
2. [학술지(정기간행물)] - Bolton DC / 1982 / Identification of a protein that purifies with the scrapie prion / Science 218 : 1309 ~ 1311
3. [학술지(정기간행물)] - Campbell IL / 1994 / Activation of cerebral cytokine gene expression and its correlation with onset of reactive astrocyte and acutephase response gene expression in scrapie / J Virol 68 : 2383 ~ 2387
4. [학술지(정기간행물)] - Choi SI / 1998 / Mitochondrial dysfunction induced by oxidative stress in the brains of hamsters infected with the 263K scrapie agent / Acta Neuropathol 96 : 279 ~ 286
5. [학술지(정기간행물)] - Choi YG / 2004 / Nonenzymatic glycation at the N terminus of pathogenic prion protein in transmissible spongiform encephalopathies / J Biol Chem 279 : 30402 ~ 30409
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