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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.9
- 수록면
- 247 - 254 (8page)
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초록· 키워드
오류제보하기
Viruses initiate a number of cellular stress responses and modulate gene regulation and compartmentalization of RNA upon infection to be successful parasites. Virus infections may induce or impair stress granule (SG) formation to maximize replication efficiency. SGs and processing bodies (PBs) are the RNA granules, which contain translationally inactive pool of transcripts as the mRNA silencing foci. PBs and SGs, the highly conserved macromolecular aggregates, can release mRNAs to allow their translations. Unlike constitutively existing PBs that can respond to stimuli and affect mRNA translation and decay, SGs are specifically induced upon cellular stress and can triggers a global translational silencing by several pathways, including phosphorylation of the key translation initiation factor eIF2alpha, tRNA cleavage, and sequestration of cellular components and so on. The dynamics of PBs and SGs are regulated by several signaling pathways, including histone deacetylase 6, and depend on microfilaments and microtubules, and the cognate molecular motors myosin, dynein, and kinesin. SGs share features with aggresomes and related aggregates of unfolded proteins and may play a role in the pathology. The recent advances in understanding the relationship between viruses and mRNA stress granules are summarized.
목차
서론
스트레스 과립의 형성과 구성성분
스트레스 과립과 바이러스의 상호작용
감염의 시작 혹은 중간단계에서 바이러스에의한 SG 억제 기전
전체 감염기간 동안의 바이러스에 의한 SG 억제 기전
SG 반응을 통한 바이러스 관용의 유도 혹은 또는 증식에 이용?
항 바이러스 반응의 중심인 SG의 기능
결론
참고문헌
참고문헌 (16)
참고문헌 신청
1. [학술지(정기간행물)] - White JP / 2012 / Regulation of stress granules in virus systems / Trends Microbiol 20 : 175 ~ 183
2. [학술지(정기간행물)] - Thomas MG / 2011 / RNA granules: the good, the bad and the ugly / Cell Signal 23 : 324 ~ 334
3. [학술지(정기간행물)] - 권소희 / 200712 / The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response / GENES & DEVELOPMENT 21 (24) : 3381 ~ 3394
4. [학술지(정기간행물)] - Qin Q / 2009 / Mammalian orthoreovirus particles induce and are recruited into stress granules at early times postinfection / J Virol 83 : 11090 ~ 11101
5. [학술지(정기간행물)] - Qin Q / 2011 / Mammalian orthoreovirus escape from host translational shutoff correlates with stress granule disruption and is independent of eIF2alpha phosphorylation and PKR / J Virol 85 : 8798 ~ 8810
2. [학술지(정기간행물)] - Thomas MG / 2011 / RNA granules: the good, the bad and the ugly / Cell Signal 23 : 324 ~ 334
3. [학술지(정기간행물)] - 권소희 / 200712 / The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response / GENES & DEVELOPMENT 21 (24) : 3381 ~ 3394
4. [학술지(정기간행물)] - Qin Q / 2009 / Mammalian orthoreovirus particles induce and are recruited into stress granules at early times postinfection / J Virol 83 : 11090 ~ 11101
5. [학술지(정기간행물)] - Qin Q / 2011 / Mammalian orthoreovirus escape from host translational shutoff correlates with stress granule disruption and is independent of eIF2alpha phosphorylation and PKR / J Virol 85 : 8798 ~ 8810
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