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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.12
- 수록면
- 337 - 341 (5page)
이용수
초록· 키워드
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Influenza virus is a serious pathogen that burdens society with health care costs, and can lead to fatality. The virus is dealt with currently by vaccination and anti-influenza drugs. However, vaccines need to be improved towards safer and more efficient production formats, and drugs need to be constantly renewed to cope with resistances. That the neuraminidase inhibitors are only drugs currently available warrants urgent attention to an alternative anti-influenza target. In this paper we introduce studies on fusion activity of influenza virus hemagglutinin (HA), and discuss how to best utilize the knowledge for an improved vaccine development and an anti-influenza drug search. Potential application of mutations resulting in changes in fusion activity to cell culture optimized vaccine virus development and strategies to develop broad spectrum anti-influenza drugs through targeting the conserved fusion domain of the HA are discussed.
목차
1. 인플루엔자바이러스 HA 단백질에 의한 융합 기작
2. HA2 단백질의 융합기능 상승을 통한 백신주 생산성 향상
3. 세포막 융합기능이 있는 HA2 단백질을 표적으로 하는 항인플루엔자 제제의 개발
결론
REFERENCES
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Ye ZP / 1987 / Functional and antigenic domains of the matrix (M1) protein of influenza A virus / J Virol 61 : 239 ~ 246
2. [학술지(정기간행물)] - Tong S / 2013 / New world bats harbor diverse influenza a viruses / PLoS Pathog 9 : e1003657 ~
4. [학술지(정기간행물)] - 김진일 / 2012 / GFP-Expressing Influenza A Virus for Evaluation of the Efficacy of Antiviral Agents / The Journal of Microbiology 50 (2) : 359 ~ 362
5. [학술지(정기간행물)] - Hamilton BS / 2012 / Influenza virusmediated membrane fusion: determinants of hemagglutinin fusogenic activity and experimental approaches for assessing virus fusion / Viruses 4 : 1144 ~ 1168
6. [학술지(정기간행물)] - 이일섭 / 2013 / Cell Culture-based Influenza Vaccines as Alternatives to Egg-based Vaccines / Journal of Bacteriology and Virology 43 (1) : 9 ~ 17
2. [학술지(정기간행물)] - Tong S / 2013 / New world bats harbor diverse influenza a viruses / PLoS Pathog 9 : e1003657 ~
4. [학술지(정기간행물)] - 김진일 / 2012 / GFP-Expressing Influenza A Virus for Evaluation of the Efficacy of Antiviral Agents / The Journal of Microbiology 50 (2) : 359 ~ 362
5. [학술지(정기간행물)] - Hamilton BS / 2012 / Influenza virusmediated membrane fusion: determinants of hemagglutinin fusogenic activity and experimental approaches for assessing virus fusion / Viruses 4 : 1144 ~ 1168
6. [학술지(정기간행물)] - 이일섭 / 2013 / Cell Culture-based Influenza Vaccines as Alternatives to Egg-based Vaccines / Journal of Bacteriology and Virology 43 (1) : 9 ~ 17
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