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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.9
- 수록면
- 154 - 162 (9page)
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초록· 키워드
오류제보하기
Dendritic cell (DC)-based cancer immunotherapy is studied for several years. However, it is mainly derived from autologous PBMC or leukapheresis from patient, which has limitations about yield and ability of DC production according to individual status. In order to solve these problems, inquiries about allogeneic DCs are performed but there are no preclinical trial answers for effect or toxicity of allogeneic DC to use for clinical trial. In this study, we compared the anti-tumor effect of allogeneic and autologous DCs from mouse bone marrow stem cells in mouse metastatic melanoma model. Methods: B16F10 melanoma cells (5×10<sup>4</sup>/mouse) were injected intravenously into the C57BL/6 mouse. Therapeutic DCs were differentiated from autologous (C57BL/6: CDC) or allogeneic (B6C3F1: BDC) bone marrow stem cells with GM-CSF, SCF and IL-4 for 13days and pulsed with B16F10 tumor cell lysate (Blys) for 18hrs. DC intra-peritoneal injections began on the 8th day after the tumor cell injection by twice with one week interval. Results: Anti-tumor response was observed by DC treatment without any toxicity especially in allogeneic DC treated mice (tumor burden score: 2.667±0.184, 2.500±0.463, 2.000±0.286, 1.500±0.286, 1.667 ±0.297 for saline, CDC/unpulsed-DC: U-DC, CDC/Blys-DC, BDC/U-DC and BDC/Blys-DC, respectively). IFN-γ secretion was significantly increased in allogeneic DC group stimulated with B16F10 cell lysate (2,643.3±5,89.7, 8,561.5±2,204.9. 6,901.2±141.1pg/1×10<sup>6</sup> cells for saline, BDC/U-DC and BDC/Blys-DC, respectively) with increased NK cell activity. Conclusion: Conclusively, promising data was obtained that allogeneic DC can be used for DC-based cancer immunotherapy.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
[학술지(정기간행물)] - / 1996 / Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells 2 : 52 ~ 58
[학술지(정기간행물)] - / 2005 / Effect of dendritic cell based cancer vaccine using allogeneic tumor cell lysate in melanoma pulmonary metastasis model 5 : 163 ~ 171
[학술지(정기간행물)] - / 2004 / Cellular immunotherapy with dendritic cells in cancer 22 : 501 ~ 513
[학술지(정기간행물)] - / 2004 / Generation of dendritic cells from positively selected CD14 monocytes for anti- tumor immunotherapy 45 : 1419 ~ 1428
[학술지(정기간행물)] - / 2004 / Dendritic cell immunotherapy 10 : 475 ~ 480
[학술지(정기간행물)] - / 2005 / Effect of dendritic cell based cancer vaccine using allogeneic tumor cell lysate in melanoma pulmonary metastasis model 5 : 163 ~ 171
[학술지(정기간행물)] - / 2004 / Cellular immunotherapy with dendritic cells in cancer 22 : 501 ~ 513
[학술지(정기간행물)] - / 2004 / Generation of dendritic cells from positively selected CD14 monocytes for anti- tumor immunotherapy 45 : 1419 ~ 1428
[학술지(정기간행물)] - / 2004 / Dendritic cell immunotherapy 10 : 475 ~ 480
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