지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.2
- 수록면
- 1 - 10 (10page)
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Interleukin-7 (IL-7) is an essential cytokine for T cells. However, IL-7 is not produced by T cells themselves such that T cells are dependent on extrinsic IL-7. In fact, in the absence of IL-7, T cell development in the thymus as well as survival of naive T cells in the periphery is severely impaired. Furthermore, modulating IL-7 availability in vivo either by genetic means or other experimental approaches determines the size, composition and function of the T cell pool. Consequently, understanding IL-7 expression is critical for understanding T cell immunity. Until most recently, however, the spatiotemporal expression of in vivo IL-7 has remained obscured. Shortage of such information was partly due to scarce expression of IL-7 itself but mainly due to the lack of adequate reagents to monitor IL-7 expression in vivo. This situation dramatically changed with a recent rush of four independent studies that describe the generation and characterization of IL-7 reporter mice, all utilizing bacterial artificial chromosome transgene technology. The emerging consensus of these studies confirmed thymic stromal cells as the major producers of IL-7 but also identified IL-7 reporter activities in various peripheral tissues including skin, intestine and lymph nodes. Strikingly, developmental and environmental cues actively modulated IL-7 reporter activities in vivo suggesting that IL-7 regulation might be a new mechanism of shaping T cell development and homeostasis. Collectively, the availability of these new tools opens up new venues to assess unanswered questions in IL-7 biology in T cells and beyond.
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참고문헌 (63)
참고문헌 신청
Namen AE / 1988 / B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors / J Exp Med 167:988~1002
Peschon JJ / 1994 / Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice / J Exp Med 180:180~1960
von Freeden-Jeffry U / 1995 / Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine / J Exp Med 181:1519~1526
Schluns KS / 2000 / Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo / Nat Immunol 21:426~432
Tan JT / 2001 / IL-7 is critical for homeostatic proliferation and survival of naive T cells / Proc Natl Acad Sci U S A 98:8732~8737
Peschon JJ / 1994 / Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice / J Exp Med 180:180~1960
von Freeden-Jeffry U / 1995 / Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine / J Exp Med 181:1519~1526
Schluns KS / 2000 / Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo / Nat Immunol 21:426~432
Tan JT / 2001 / IL-7 is critical for homeostatic proliferation and survival of naive T cells / Proc Natl Acad Sci U S A 98:8732~8737
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