지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 169 - 174 (6page)
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NADPH oxidase (NOX) modulates cell proliferation, differentiation and immune response through generation of reactive oxygen species. Particularly, NOX2 is recently reported to be important for regulating Treg cell differentiation of CD4+ T cells. Methods: We employed ovalbumin-induced airway inflammation in wild-type and NOX2-deficient mice and analyzed tissue histopathology and cytokine profiles. Results: We investigated whether NOX2-deficiency affects T cell-mediated airway inflammation. Ovalbumin injection which activates T cell-mediated allergic response increased airway inflammation in wild-type mice, as evidenced by increased immune cell infiltration, allergic cytokine expression, and goblet cell hyperplasia in the lung. Interestingly, NOX2 knockout (KO) mice were more susceptible to allergen-induced lung inflammation compared to wild-type mice. Immune cells including neutrophils, lymphocytes, macrophages, and eosinophils were drastically infiltrated into the lung of NOX2 KO mice and mucus secretion was substantially increased in deficiency of NOX2. Furthermore, inflammatory allergic cytokines and eotaxin were significantly elevated in NOX2 KO mice, in accordance with enhanced generation of inflammatory cytokines interleukin-17 and interferon-γ by CD4+ T cells. Conclusion: These results indicate that NOX2 deficiency favorably produces inflammatory cytokines by T cells and thus increases the susceptibility to severe airway inflammation.
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참고문헌 (17)
참고문헌 신청
Groemping Y / 2003 / Molecular basis of phosphorylation-induced activation of the NADPH oxidase / Cell 113:343~355
Bedard K / 2007 / The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology / Physiol Rev 87:245~313
Thannickal VJ / 2000 / Reactive oxygen species in cell signaling / Am J Physiol Lung Cell Mol Physiol 279:L1005~L1028
Phillips DC / 2010 / Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): causes and consequences for immune function, cell survival, and therapeutic intervention / Antioxid Redox Signal 12:743~785
Lambeth JD / 2004 / NOX enzymes and the biology of reactive oxygen / Nat Rev Immunol 4:181~189
Bedard K / 2007 / The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology / Physiol Rev 87:245~313
Thannickal VJ / 2000 / Reactive oxygen species in cell signaling / Am J Physiol Lung Cell Mol Physiol 279:L1005~L1028
Phillips DC / 2010 / Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): causes and consequences for immune function, cell survival, and therapeutic intervention / Antioxid Redox Signal 12:743~785
Lambeth JD / 2004 / NOX enzymes and the biology of reactive oxygen / Nat Rev Immunol 4:181~189
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