지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 324 - 335 (12page)
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초록· 키워드
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The human leukocyte antigen (HLA), the major histocompatibility complex (MHC) in humans has been known to reside on chromosome 6 and encodes cell-surface antigen-presenting proteins and many other proteins related to immune system function. The HLA is highly polymorphic and the most genetically variable coding loci in humans. In addition to a critical role in transplantation medicine, HLA and disease associations have been widely studied across the populations worldwide and are found to be important in prediction of disease susceptibility, resistance and of evolutionary maintenance of genetic diversity. Because recently developed molecular based HLA typing has several advantages like improved specimen stability and increased resolution of HLA types, the association between HLA alleles and a given disease could be more accurately quantified. Here, in this review, we have collected HLA association data on some autoimmune diseases, infectious diseases, cancers, drug responsiveness and other diseases with unknown etiology in Koreans and attempt to summarize some remarkable HLA alleles related with specific diseases.
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참고문헌 (58)
참고문헌 신청
1. [학술지(정기간행물)] - Ghodke Y / 2005 / HLA and disease / Eur J Epidemiol 20 : 475 ~ 488
2. [학술지(정기간행물)] - Shiina T / 2004 / An update of the HLA genomic region, locus information and disease associations: 2004 / Tissue Antigens 64 : 631 ~ 649
3. [학술지(정기간행물)] - Nepom GT / 1995 / Class II antigens and disease susceptibility / Annu Rev Med 46 : 17 ~ 25
4. [학술지(정기간행물)] - Ota M / 2001 / A second susceptibility gene for developing rheumatoid arthritis in the human MHC is localized within a 70-kb interval telomeric of the TNF genes in the HLA class III region / Genomics 71 : 263 ~ 270
5. [학술지(정기간행물)] - The International HIV Controllers Study / 2010 / the major genetic determinants of HIV-1 control affect HLA class I peptide presentation / Science 330 : 1488 ~ 1490
2. [학술지(정기간행물)] - Shiina T / 2004 / An update of the HLA genomic region, locus information and disease associations: 2004 / Tissue Antigens 64 : 631 ~ 649
3. [학술지(정기간행물)] - Nepom GT / 1995 / Class II antigens and disease susceptibility / Annu Rev Med 46 : 17 ~ 25
4. [학술지(정기간행물)] - Ota M / 2001 / A second susceptibility gene for developing rheumatoid arthritis in the human MHC is localized within a 70-kb interval telomeric of the TNF genes in the HLA class III region / Genomics 71 : 263 ~ 270
5. [학술지(정기간행물)] - The International HIV Controllers Study / 2010 / the major genetic determinants of HIV-1 control affect HLA class I peptide presentation / Science 330 : 1488 ~ 1490
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