지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 416 - 419 (4page)
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초록· 키워드
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Dextran sodium sulfate (DSS) is a widely used chemical model for inflammatory bowel disease (IBD). It is thought that imbalances in the T helper (Th) cell subsets contribute to IBD. Recent studies suggest that the acute DSS-colitis model is polarized toward a Th1/Th17 profile based on RT-PCR analysis of colonic tissues. In the current study we determined whether colonic Th cells from DSS-colitis mice were skewed toward the Th17 profile. Mice were treated with 5% DSS for 7 days and colonic T cells isolated and examined for production of IFN-γ (Th1 cell), IL-4 (Th2 cell) and IL-17 (Th17 cell) by intracellular flow cytometry. We found that the percentage of colonic Th17 cells were similar to non-treated controls but the percentage of Th1 cells were elevated in DSS-colitis mice. These results suggest that in the acute DSS-colitis model the colonic Th cells exhibit a Th1 profile and not a Th17 profile.
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참고문헌 (19)
참고문헌 신청
Xavier RJ / 2007 / Unravelling the pathogenesis of inflammatory bowel disease / Nature 448:427~434
Strober W / 2007 / The fundamental basis of inflammatory bowel disease / J Clin Invest 117:514~521
Strober W / 2008 / Why study animal models of IBD / Inflamm Bowel Dis 14(2):S129~S131
Okayasu I / 1990 / A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice / Gastroenterology 98:694~702
Pizarro TT / 2007 / Cytokine therapy for Crohn's disease: advances in translational research / Annu Rev Med 58:433~444
Strober W / 2007 / The fundamental basis of inflammatory bowel disease / J Clin Invest 117:514~521
Strober W / 2008 / Why study animal models of IBD / Inflamm Bowel Dis 14(2):S129~S131
Okayasu I / 1990 / A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice / Gastroenterology 98:694~702
Pizarro TT / 2007 / Cytokine therapy for Crohn's disease: advances in translational research / Annu Rev Med 58:433~444
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