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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.2
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- 1 - 7 (7page)
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Interleukin-24 (IL-24) belongs to the IL-10 family of cytokines and is well known for its tumor suppressor activity. This cytokine is released by both immune and nonimmune cells and acts on non-hematopoietic tissues such as skin, lung and reproductive tissues. Apart from its ubiquitous tumor suppressor function, IL-24 is also known to be involved in the immunopathology of autoimmune diseases like psoriasis and rheumatoid arthritis. Although the cellular sources and functions of IL-24 are being increasingly investigated, the molecular mechanisms of IL-24 gene expression at the levels of signal transduction, epigenetics and transcription factor binding are still unclear. Understanding the specific molecular events that regulate the production of IL-24 will help to answer the remaining questions that are important for the design of new strategies of immune intervention involving IL-24. Herein, we briefly review the signaling pathways and transcription factors that facilitate, induce, or repress production of this cytokine along with the cellular sources and functions of IL-24.
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참고문헌 (63)
참고문헌 신청
1. [학술지(정기간행물)] - Boehm U / 1997 / Cellular responses to interferon-gamma / Annu Rev Immunol 15 : 749 ~ 795
2. [학술지(정기간행물)] - Li-Weber M / 2003 / Regulation of IL4 gene expression by T cells and therapeutic perspectives / Nat Rev Immunol 3 : 534 ~ 443
3. [학술지(정기간행물)] - Saraiva M / 2010 / The regulation of IL-10 production by immune cells / Nat Rev Immunol 10 : 170 ~ 181
4. [학술지(정기간행물)] - Rennick DM / 1997 / Studies with IL-10-/- mice: an overview / J Leukoc Biol 61 : 389 ~ 396
5. [학술지(정기간행물)] - 임신혁 / 200411 / Chromatin-level regulation of the IL10 gene in T cells / JOURNAL OF BIOLOGICAL CHEMISTRY 279 (45) : 46818 ~ 46825
2. [학술지(정기간행물)] - Li-Weber M / 2003 / Regulation of IL4 gene expression by T cells and therapeutic perspectives / Nat Rev Immunol 3 : 534 ~ 443
3. [학술지(정기간행물)] - Saraiva M / 2010 / The regulation of IL-10 production by immune cells / Nat Rev Immunol 10 : 170 ~ 181
4. [학술지(정기간행물)] - Rennick DM / 1997 / Studies with IL-10-/- mice: an overview / J Leukoc Biol 61 : 389 ~ 396
5. [학술지(정기간행물)] - 임신혁 / 200411 / Chromatin-level regulation of the IL10 gene in T cells / JOURNAL OF BIOLOGICAL CHEMISTRY 279 (45) : 46818 ~ 46825
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