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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.10
- 수록면
- 189 - 195 (7page)
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It has been reported that vitamin C plays an effective role in the treatment and prevention of cancer, but its specific mechanisms are still largely unknown. The incidence of colon cancer is now increasing in Korea. Therefore, we have examined here the effect of vitamin C on the induction of the apoptosis on colon cancer and its related mechanisms. We have found that remarkable increase of the apoptosis and the calcium influx in endoplasmic reticulum (ER) in human colon cancer cell line, HCT-8. However, vitamin C-induced apoptosis was effectively inhibited by the pre-treatment of BAPTA-AM (1,2-bis(o-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid), which is well-known as a calcium specific chelator. During the apoptosis, we found the increase of the translocation of Bad to mitochondria from cytosol, after releasing from 14-3-3β. In this process, the expression of Bax, a well-known pro-apoptotic protein, was also increased. Taken together, vitamin C induces apoptosis of colon cancer cell line, HCT-8 through the increase of 1) the calcium influx in endoplasmic reticulum (ER), 2) the translocation of Bad to mitochondria, and 3) the expression of Bax.
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참고문헌 (35)
참고문헌 신청
Kang, J. S. / 2003 / L-ascorbic acid (vitamin C) induces the apoptosis of B16 murine melanoma cells via a caspase-8-independent pathway / Cancer Immunol. Immunother 52:693~698
Kang, J. S / 2005 / Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake / J. Cell. Physiol 204:192~197
Kim, J. E / 2008 / Vitamin C inhibits p53-induced replicative senescence through suppression of ROS production and p38 MAPK activity / Int. J. Mol. Med 22:651~655
Hahm, E. / 2007 / The molecular mechanisms of vitamin C on cell cycle regulation in B16F10 murine melanoma / J. Cell. Biochem 102:1002~1010
Lee, S. K. / 2008 / Vitamin C suppresses proliferation of the human melanoma cell SK-MEL-2 through the inhibition of cyclooxygenase-2 (COX-2) expression and the modulation of insulin-like growth factor II (IGF-II) production / J. Cell. Physiol 216:180~188
Kang, J. S / 2005 / Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake / J. Cell. Physiol 204:192~197
Kim, J. E / 2008 / Vitamin C inhibits p53-induced replicative senescence through suppression of ROS production and p38 MAPK activity / Int. J. Mol. Med 22:651~655
Hahm, E. / 2007 / The molecular mechanisms of vitamin C on cell cycle regulation in B16F10 murine melanoma / J. Cell. Biochem 102:1002~1010
Lee, S. K. / 2008 / Vitamin C suppresses proliferation of the human melanoma cell SK-MEL-2 through the inhibition of cyclooxygenase-2 (COX-2) expression and the modulation of insulin-like growth factor II (IGF-II) production / J. Cell. Physiol 216:180~188
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