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- 자료유형
- 학술저널
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- 2014.2
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Epstein-Barr virus (EBV) is etiologically associated with a variety of diseases including lymphoproliferative diseases, lymphomas, carcinomas, and autoimmune diseases. Humans are the only natural host of EBV and limited species of new-world monkeys can be infected with the virus in experimental conditions. Small animal models of EBV infection, required for evaluation of novel therapies and vaccines for EBV-associated diseases, have not been available. Recently the development of severely immunodeficient mouse strains enabled production of humanized mice in which human immune system components are reconstituted and express their normal functions. Humanized mice can serve as infection models for human-specific viruses such as EBV that target cells of the immune system. This review summarizes recent studies by the author's group addressing reproduction of EBV infection and pathogenesis in humanized mice.
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참고문헌 (38)
참고문헌 신청
1. [단행본] - Longnecker, R. M. / 2013 / Fields Virology / Lippincott Williams and Wlikins : 1898 ~ 1959
2. [학술지(정기간행물)] - Hislop, A. D. / 2007 / Cellular responses to viral infection in humans: lessons from Epstein-Barr virus / Annu. Rev. Immunol 25 : 587 ~ 617
3. [학술지(정기간행물)] - Shope, T. / 1973 / Malignant lymphoma in cottontop marmosets after inoculation with Epstein-Barr virus / Proc. Natl. Acad. Sci. USA 70 : 2487 ~ 2491
4. [학술지(정기간행물)] - Epstein, M. A. / 1975 / Pilot experiments with EB virus in owl monkeys (Aotus trivirgatus). III. Serological and biochemical findings in an animal with reticuloproliferative disease / Int. J. Cancer 15 : 17 ~ 22
5. [학술지(정기간행물)] - Johannessen, I. / 1999 / In vivo models for Epstein-Barr virus (EBV)-associated B cell lymphoproliferative disease (BLPD) / Rev. Med. Virol 9 : 263 ~ 277
2. [학술지(정기간행물)] - Hislop, A. D. / 2007 / Cellular responses to viral infection in humans: lessons from Epstein-Barr virus / Annu. Rev. Immunol 25 : 587 ~ 617
3. [학술지(정기간행물)] - Shope, T. / 1973 / Malignant lymphoma in cottontop marmosets after inoculation with Epstein-Barr virus / Proc. Natl. Acad. Sci. USA 70 : 2487 ~ 2491
4. [학술지(정기간행물)] - Epstein, M. A. / 1975 / Pilot experiments with EB virus in owl monkeys (Aotus trivirgatus). III. Serological and biochemical findings in an animal with reticuloproliferative disease / Int. J. Cancer 15 : 17 ~ 22
5. [학술지(정기간행물)] - Johannessen, I. / 1999 / In vivo models for Epstein-Barr virus (EBV)-associated B cell lymphoproliferative disease (BLPD) / Rev. Med. Virol 9 : 263 ~ 277
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