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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.2
- 수록면
- 45 - 53 (9page)
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초록· 키워드
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Osteoarthritis (OA) is a degenerative joint disease characterized by a progressive loss of cartilage. And, increased oxidative stress plays a relevant role in the pathogenesis of OA. Ursodeoxycholic acid (UDCA) is a used drug for liver diseases known for its free radical-scavenging property. The objectives of this study were to investigate the in vivo effects of UDCA on pain severity and cartilage degeneration using an experimental OA model and to explore its mode of actions. OA was induced in rats by intra-articular injection of monosodium iodoacetate (MIA) to the knee. Oral administration UDCA was initiated on the day of MIA injection. Limb nociception was assessed by measuring the paw withdrawal latency and threshold. Samples were analyzed macroscopically and histologically. Immunohistochemistry was used to investigate the expression of interleukin-1β (IL-1β), IL-6, nitrotyrosine and inducible nitric oxide synthase (iNOS) in knee joints. UDCA showed an antinociceptive property and attenuated cartilage degeneration. OA rats given oral UDCA significantly exhibited a decreased number of osteoclasts in subchondral bone legion compared with the vehicle-treated OA group. UDCA reduced the expression of IL-1β, IL-6, nitrotyrosine and iNOS in articular cartilage. UDCA treatment significantly attenuated the mRNA expression of matrix metalloproteinase-3 (MMP-3), -13, and ADAMTS5 in IL-1β-stimulated human OA chondrocytes. These results show the inhibitory effects of UDCA on pain production and cartilage degeneration in experimentally induced OA. The chondroprotective properties of UDCA were achieved by suppressing oxidative damage and inhibiting catabolic factors that are implicated in the pathogenesis of cartilage damage in OA.
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참고문헌 (33)
참고문헌 신청
1. [학술지(정기간행물)] - Felson, D. T. / 2006 / Clinical practice. Osteoarthritis of the knee / N. Engl. J. Med 354 : 841 ~ 848
2. [학술지(정기간행물)] - Chadjichristos, C. / 2003 / Sp1 and Sp3 transcription factors mediate interleukin-1 beta down-regulation of human type II collagen gene expression in articular chondrocytes / J. Biol. Chem 278 : 39762 ~ 39772
3. [학술지(정기간행물)] - Guerne, P. A. / 1990 / IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro / J. Immunol 144 : 499 ~ 505
4. [학술지(정기간행물)] - Remans, P. H. / 2006 / CTLA-4IG suppresses reactive oxygen species by preventing synovial adherent cell-induced inactivation of Rap1, a Ras family GTPASE mediator of oxidative stress in rheumatoid arthritis T cells / Arthritis Rheum 54 : 3135 ~ 3143
5. [학술지(정기간행물)] - Najim, R. A. / 2007 / Oxidative stress in patients with Behcet's disease: I correlation with severity and clinical parameters / J. Dermatol 34 : 308 ~ 314
2. [학술지(정기간행물)] - Chadjichristos, C. / 2003 / Sp1 and Sp3 transcription factors mediate interleukin-1 beta down-regulation of human type II collagen gene expression in articular chondrocytes / J. Biol. Chem 278 : 39762 ~ 39772
3. [학술지(정기간행물)] - Guerne, P. A. / 1990 / IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro / J. Immunol 144 : 499 ~ 505
4. [학술지(정기간행물)] - Remans, P. H. / 2006 / CTLA-4IG suppresses reactive oxygen species by preventing synovial adherent cell-induced inactivation of Rap1, a Ras family GTPASE mediator of oxidative stress in rheumatoid arthritis T cells / Arthritis Rheum 54 : 3135 ~ 3143
5. [학술지(정기간행물)] - Najim, R. A. / 2007 / Oxidative stress in patients with Behcet's disease: I correlation with severity and clinical parameters / J. Dermatol 34 : 308 ~ 314
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