지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.12
- 수록면
- 328 - 332 (5page)
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초록· 키워드
오류제보하기
Dexamethasone (Dex) was shown to inhibit the differentiation, maturation, and antigen-presenting function of dendritic cells (DC) when added during DC generation or maturation stages. Here, we examined the direct effects of Dex on MHC-restricted antigen processing. Macrophages were incubated with microencapsulated ovalbumin (OVA) in the presence of different concentrations of Dex for 2 h, and the efficacy of OVA peptide presentation was evaluated using OVA-specific CD8 and CD4 T cells. Dex inhibited both class I- and class II-restricted presentation of OVA to T cells; this inhibitory effect on antigen presentation was much more potent in immature macrophages than in mature macrophages. The presentation of the exogenously added OVA peptide SIINFEKL was not blocked by Dex. In addition, short-term treatment of macrophages with Dex had no discernible effects on the phagocytic activity, total expression levels of MHC molecules or co-stimulatory molecules. These results demonstrate that Dex inhibits intracellular processing events of phagocytosed antigens in macrophages.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (25)
참고문헌 신청
1. [학술지(정기간행물)] - Boumpas, D. T. / 1991 / Glucocorticosteroid action on the immune system: molecular and cellular aspects / Clin. Exp. Rheumatol 9 : 413 ~ 423
2. [학술지(정기간행물)] - Marx, J / 1995 / How the glucocorticoids suppress immunity / Science 270 : 232 ~ 233
3. [학술지(정기간행물)] - Kitajima, T. / 1996 / A novel mechanism of glucocorticoid-induced immune suppression: the inhibiton of T cell-mediated terminal maturation of a murine dendritic cell line / J. Clin. Invest 98 : 142 ~ 147
4. [학술지(정기간행물)] - Arya, S. K. / 1984 / Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA / J. Immunol 133 : 273 ~ 276
5. [학술지(정기간행물)] - Culpepper, J. A / 1985 / Regulation of IL 3 expression by glucocorticoids in cloned murine T lymphocytes / J. Immunol 135 : 3191 ~ 3197
2. [학술지(정기간행물)] - Marx, J / 1995 / How the glucocorticoids suppress immunity / Science 270 : 232 ~ 233
3. [학술지(정기간행물)] - Kitajima, T. / 1996 / A novel mechanism of glucocorticoid-induced immune suppression: the inhibiton of T cell-mediated terminal maturation of a murine dendritic cell line / J. Clin. Invest 98 : 142 ~ 147
4. [학술지(정기간행물)] - Arya, S. K. / 1984 / Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA / J. Immunol 133 : 273 ~ 276
5. [학술지(정기간행물)] - Culpepper, J. A / 1985 / Regulation of IL 3 expression by glucocorticoids in cloned murine T lymphocytes / J. Immunol 135 : 3191 ~ 3197
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UCI(KEPA) : I410-ECN-0101-2016-511-001754239