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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.2
- 수록면
- 44 - 49 (6page)
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Interactions between microbes and epithelial cells in the gastrointestinal tract are closely associated with regulation of intestinal mucosal immune responses. Recent studies have highlighted the modulation of mucosal immunity by microbe-derived molecules such as ATP and short-chain fatty acids. In this study, we undertook to characterize the expression of the ATP-gated P2X<SUB>7</SUB> receptor (P2X<SUB>7</SUB>R) on M cells and its role in gastrointestinal mucosal immune regulation because it was poorly characterized in Peyer’s patches, although purinergic signaling via P2X<SUB>7</SUB>R and luminal ATP have been considered to play an important role in the gastrointestinal tract. Here, we present the first report on the expression of P2X<SUB>7</SUB>R on M cells and characterize the role of P2X<SUB>7</SUB>R in immune enhancement by ATP or LL-37.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2016-511-001754562