지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.4
- 수록면
- 73 - 82 (10page)
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초록· 키워드
오류제보하기
Respiratory syncytial virus (RSV) infection is recognized by the innate immune system through Toll like receptors (TLRs) and retinoic acid inducible gene I. These pathways lead to the activation of type I interferons and resistance to infection. In contrast to TLRs, very few studies have examined the role of NOD-like receptors in viral recognition and induction of adaptive immune responses to RSV. Caspase-1 plays an essential role in the immune response via the maturation of the proinflammatory cytokines IL-1β and IL-18. However, the role of caspase-1 in RSV infection in vivo is unknown. We demonstrate that RSV infection induces IL-1β secretion and that caspase-1 deficiency in bone marrow derived dendritic cells leads to defective IL-1β production, while normal RSV viral clearance and T cell responses are observed in caspase-1 deficient mice following respiratory infection with RSV. The frequencies of IFN-γ producing or RSV specific T cells in lungs from caspase-1 deficient mice are not impaired. In addition, we demonstrate that caspase-1 deficient neonatal or young mice also exhibit normal immune responses. Furthermore, we find that IL-1R deficient mice infected with RSV exhibit normal Th1 and cytotoxic T lymphocytes (CTL) immune responses. Collectively, these results demonstrate that in contrast to TLR pathways, caspase-1 might not play a central role in the induction of Th1 and CTL immune responses to RSV.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (32)
참고문헌 신청
1. [단행본] - Collins, P. L. / 1991 / The molecular biology of human respiratory syncytial virus (RSV) of the genus Pneumovirus / Springer. Plenum Press : 103 ~ 162
2. [학술지(정기간행물)] - Collins, P. L. / 2008 / Viral host factors in human respiratory syncytial virus pathogenesis / J. Virol 82 : 2040 ~ 2055
3. [학술지(정기간행물)] - Falsey, A. R. / 2005 / Respiratory syncytial virus infection in elderly high-risk adults / N. Engl. J. Med 352 : 1749 ~ 1759
4. [학술지(정기간행물)] - Sollberger, G. / 2014 / Caspase-1: the inflammasome beyond / Innate. Immun 20 : 115 ~ 125
5. [학술지(정기간행물)] - Case, C. L. / 2011 / Regulating caspase-1 during infection: roles of NLRs, AIM2, ASC / Yale J. Biol. Med 84 : 333 ~ 343
2. [학술지(정기간행물)] - Collins, P. L. / 2008 / Viral host factors in human respiratory syncytial virus pathogenesis / J. Virol 82 : 2040 ~ 2055
3. [학술지(정기간행물)] - Falsey, A. R. / 2005 / Respiratory syncytial virus infection in elderly high-risk adults / N. Engl. J. Med 352 : 1749 ~ 1759
4. [학술지(정기간행물)] - Sollberger, G. / 2014 / Caspase-1: the inflammasome beyond / Innate. Immun 20 : 115 ~ 125
5. [학술지(정기간행물)] - Case, C. L. / 2011 / Regulating caspase-1 during infection: roles of NLRs, AIM2, ASC / Yale J. Biol. Med 84 : 333 ~ 343
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UCI(KEPA) : I410-ECN-0101-2016-511-001746311