지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.8
- 수록면
- 157 - 162 (6page)
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초록· 키워드
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Application of vaccine materials through oral mucosal route confers great economical advantage in animal farming industry due to much less vaccination cost compared with that of injection-based vaccination. In particular, oral administration of recombinant protein antigen against foot-and- mouth disease virus (FMDV) is an ideal strategy because it is safe from FMDV transmission during vaccine production and can induce antigen-specific immune response in mucosal compartments, where FMDV infection has been initiated, which is hardly achievable through parenteral immunization. Given that effective delivery of vaccine materials into immune inductive sites is prerequisite for effective oral mucosal vaccination, M cell-targeting strategy is crucial in successful vaccination since M cells are main gateway for luminal antigen influx into mucosal lymphoid tissue. Here, we applied previously identified M cell-targeting ligand Co1 to VP1 of FMDV in order to test the possible oral mucosal vaccination against FMDV infection. M cell-targeting ligand Co1-conjugated VP1 interacted efficiently with M cells of Peyer’s patch. In addition, oral administration of ligand-conjugated VP1 enhanced the induction of VP1-specific IgG and IgA responses in systemic and mucosal compartments, respectively, in comparison with those from oral administration of VP1 alone. In addition, the enhanced VP1-specific immune response was found to be due to antigen-specific Th2-type cytokine production. Collectively, it is suggested that the M cell-targeting strategy could be applied to develop efficient oral mucosal vaccine against FMDV infection.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (20)
참고문헌 신청
1. [학술지(정기간행물)] - O'Donnell, V. / 2005 / Analysis of foot-and-mouth disease virus internalization events in cultured cells / J. Virol 79 : 8506 ~ 8518
2. [학술지(정기간행물)] - Rodriguez, L. L / 2009 / Foot and mouth disease virus vaccines / Vaccine 27 (Suppl 4) : D90 ~ D94
3. [학술지(정기간행물)] - Zhang, L. J. / 2011 / Research in advance for FMD novel vaccines / Virol. J 8 : 268 ~
4. [학술지(정기간행물)] - Cubillos, C. / 2008 / Enhanced mucosal immunoglobulin A response and solid protection against foot-and-mouth disease virus challenge induced by a novel dendrimeric peptide / J. Virol 82 : 7223 ~ 7230
5. [학술지(정기간행물)] - Mestecky, J. / 2008 / Oral immunization: an update / Curr. Opin. Gastroenterol 24 : 713 ~ 719
2. [학술지(정기간행물)] - Rodriguez, L. L / 2009 / Foot and mouth disease virus vaccines / Vaccine 27 (Suppl 4) : D90 ~ D94
3. [학술지(정기간행물)] - Zhang, L. J. / 2011 / Research in advance for FMD novel vaccines / Virol. J 8 : 268 ~
4. [학술지(정기간행물)] - Cubillos, C. / 2008 / Enhanced mucosal immunoglobulin A response and solid protection against foot-and-mouth disease virus challenge induced by a novel dendrimeric peptide / J. Virol 82 : 7223 ~ 7230
5. [학술지(정기간행물)] - Mestecky, J. / 2008 / Oral immunization: an update / Curr. Opin. Gastroenterol 24 : 713 ~ 719
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UCI(KEPA) : I410-ECN-0101-2016-511-001746119