지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Phosphodiesterase type 5 inhibitors (PDE-5 inhibitors) are used in the treatment of erectile dysfunction. In recent years, a number of reports have been conducted on dietary supplements contaminated with PDE-5 analogues. In this study, 58 analogues of PDE-5 inhibitors were sorted into five groups: tadalafil, sildenafil, hongdenafil, vardenafil, and other analogues. These analogues were then evaluated using a liquid chromatographyquadrupole-time of flight mass spectrometry (LC-QTOF-MS) electrospray ionization mass method. Each compound has a unique fragmentation ion, which can be easily analyzed qualitatively. The fragmentation pathways of the analogues were elucidated based on the QTOF-MS and MS/MS data. Common ions were confirmed for each group by analyzing the structural characteristics and fragmentation pathways. Specifically, common ions were observed at m/z 169.08 and 135.04 (tadalafil analogues), m/z 311.15 and 283.12 (sildenafil analogues and hongdenafil analogues), and m/z 312.16 and 151.09 (vardenafil analogues). The advantage of this method is that the structure of unknown components can be determined by interpreting the product ions. Hence, the developed method can be used for the identification of unknown compounds. Fragmentation pathways may also aid in the detection and identification of PDE-5 inhibitor analogues.
목차
Abstract
1. Introduction
2. Experimental
3. Results and discussion
4. Conclusion
References
참고문헌 (33)
참고문헌 신청
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[학술지(정기간행물)] - L. Blok-Tip / 2004 / / Food Addit. Contam 21 (8) : 737 ~ 748
[학술지(정기간행물)] - Q. Liang / 2006 / / J. Pharm. Biomed. Anal 40 (2) : 305 ~ 311
[학술지(정기간행물)] - S. R. Gratz / 2004 / / J. Pharm. Biomed. Anal 36 (3) : 525 ~ 533
[학술지(정기간행물)] - M. H. Shin / 2003 / / Food Addit. Contam 20 (9) : 793 ~ 798
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UCI(KEPA) : I410-ECN-0101-2016-433-001790743