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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.10
- 수록면
- 451 - 456 (6page)
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Purpose: Neuronal apoptotic events induced by aging and hypoxic/ischemic conditions is an important risk factor in neurodegenerative diseases such as ischemia stroke and Alzheimer"s disease. The peel of Citrus sunki Hort. ex Tanaka has long been used as a traditional medicine, based on multiple biological activities including anti-oxidant, anti-inflammation, and anti-obesity. In the current study, we examined the actions of fermented C. sunki peel extract against cobalt chloride (CoCl₂)-mediated hypoxic death in human neuroblastoma SH-SY5Y cells. Methods: Cell viability was measured by trypan blue exclusion. Expression of apoptosis related proteins and release of cytochrome c were detected by western blot. Production of intracellular reactive oxygen species (ROS) and apoptotic morphology were examined using 2",7"- dichlorofluorescin diacetate (DCF-DA) and 4",6-diamidino-2-phenylindole (DAPI) staining. Results: Exposure to CoCl₂, a well-known mimetic agent of hypoxic/ischemic condition, resulted in neuronal cell death via caspase-3 dependent pathway. Extract of fermented C. sunki peel significantly rescued the CoCl₂-induced neuronal toxicity with the cell viability and appearance of apoptotic morphology. Cytoprotection with fermented C. sunki peel extract was associated with a decrease in activities of caspase-3 and cleavage of poly (ADP ribose) polymerase (PARP). In addition, increase in the intracellular ROS and release of cytochrome c from mitochondria to the cytosol were inhibited by treatment with extract of fermented C. sunki peel. Conclusion: Based on these data, fermented C. sunki peel extract might have a protective effect against CoCl₂-induced neuronal injury partly through generation of ROS and effectors involved in mitochondrial mediated apoptosis.
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ABSTRACT
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연구방법
결과 및 고찰
References
참고문헌 (23)
참고문헌 신청
[인터넷자원] - World Health Organization / / The top 10 causes of death
[인터넷자원] - Statistics Korea / / 2013 Cause of death statistics
[학술지(정기간행물)] - Broughton BR / 2009 / Apoptotic mechanisms after cerebral ischemia / Stroke 40 (5) : e331 ~ e339
[학술지(정기간행물)] - Fan X / 2014 / Combination approaches to attenuate hemorrhagic transformation after tPA thrombolytic therapy in patients with poststroke hyperglycemia/diabetes / Adv Pharmacol 71 : 391 ~ 410
[학술지(정기간행물)] - Ghosh N / 2014 / Advances in herbal medicine for treatment of ischemic brain injury / Nat Prod Commun 9 (7) : 1045 ~ 1055
[인터넷자원] - Statistics Korea / / 2013 Cause of death statistics
[학술지(정기간행물)] - Broughton BR / 2009 / Apoptotic mechanisms after cerebral ischemia / Stroke 40 (5) : e331 ~ e339
[학술지(정기간행물)] - Fan X / 2014 / Combination approaches to attenuate hemorrhagic transformation after tPA thrombolytic therapy in patients with poststroke hyperglycemia/diabetes / Adv Pharmacol 71 : 391 ~ 410
[학술지(정기간행물)] - Ghosh N / 2014 / Advances in herbal medicine for treatment of ischemic brain injury / Nat Prod Commun 9 (7) : 1045 ~ 1055
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